🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

Loss of gene expression can compromise cellular fitness. In the case of such haploinsufficiency, replacement of the gene supplementation could rescue cell health. But what if you need a very precise dosage? Try ComMAND! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

The saddest thing about this is academic science doesn’t reward software development, and many fields have serious tech debt that’s a huge drag on scientific productivity.

Designing DNA-binding proteins shouldn’t require structures. ❌🧬 With DPAC, we align protein and DNA language models via contrastive learning -- then use simulated annealing to design new binders straight from sequence! 🔀 📜: biorxiv.org/content/10.110… 💻: github.com/programmablebi…

Automating experiments with AI is going to be really hard because automation is way less about high-dimensional Bayesian optimization than it is about figuring out why there are bubbles in your syringe pump line

Biomanufacturing 2.0 mackenziemorehead.com/dozens-of-nobe…

NIH cuts threaten biomedical research. Gladstone President Deepak Srivastava explains why with The Voice of San Francisco bit.ly/3YXvnzI

live today! proud to have presented and contributed to the curriculum in the open-access ISSCR course, Stem Cell Medicine: From Research to Patient Care, jointly with harvard med! This resource is a major milestone for the field at such a pivotal time. invt.io/1txb7nt8018

Excited for Huaigeng Xu’s talk “Engineered Universal iPSC-derived Dendritic Cells Dressed with Tumor-MHC-Peptide Complexes as a Cancer Vaccine,” at ISSCR 2025 session on AI and Cancer Evolution Friday 8:30 am. #isscr2025 @ucsfurology, @ucsf @ucsfcancer @ucsfstemcell California Institute for Regenerative Medicine

NIH grants are in purgatory or being terminated left and right... but my F32 uh gets a small budget increase? Posting for public transparency, not clear in the NoA why the change yet #science #nih #grants

Amazing talk by Emma J Chory about directed evolution, robotics and automation. Also very interesting links for education #SEED2025

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein

The next chapter of my lab's story begins today at Penn as I join the faculty of Penn Bioengineering and Penn Computer and Information Science! ❤️💙 My wonderful students and I will continue to push the frontiers of generative algorithm theory to design and translate next-gen biologics for unmet/rare indications

All NIH-backed research now has to be publicly accessible on the day it's published. No more delays, no more waiting around, no more futzing with DOIs and having to pay journals. It's free.

Taco Bell Labs

So, is this a job offer?

A sad day for research. The reduced funding in the USA will impact the entire scientific community & slow our progress. We cannot avoid the pain, but we can mitigate it. Let's support each other, facilitate data reuse & sustain the intellectual fire of rigorous science.

*Easter egg alert* NOT in the published paper. We also benchmarked Evo 2 and while it did better than other gLMs (consistent that scale can improve gLMs), it still falls short of a basic CNN trained using one-hot sequences and far short of supervised SOTA x.com/pkoo562/status…

Why Is Discovery Research So Important? UCSF Broad Stem Cell member Grae Davis unpacks how big breakthroughs happen and why public understanding of science matters: magazine.ucsf.edu/why-discovery-…

Some students can be ridiculously hypersecretive about their research (like concealing gene lists that are anyway in the public domain). Over time, they realize that not only nobody will steal their ideas, but that they'll be lucky if anybody is interested in them.