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In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Congratulations to the ⁦Gilliard Group⁩ members graduating from Massachusetts Institute of Technology (MIT)! Proud of you and what you have accomplished!

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Excited to be at the Boston Bacterial Meeting (BBM) Meeting this year! I'll be a panelist at the AI in biology breakout session on Tuesday 6/10 after lunch, in Hall A -- together with Yunha Hwang and M.S. Suryateja Jammalamadaka. Come join us for what should be a great discussion!

We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) biorxiv.org/content/10.110…

quick reminder to join us at Massachusetts Institute of Technology (MIT) tonight for a great #RNA talk by Silvi Rouskin!

Congratulations to Elçin Ünal on her promotion to MCB Professor of Genetics, Genomics, Evolution, and Development! 👏🎉 mcb.berkeley.edu/news-and-event…

We were thrilled to see our co-founder Yunha Hwang speak at BBM Meeting yesterday on a panel about how AI is reshaping biological research. Thank you to the BBM team for putting together such a thoughtful event! One clear takeaway: there’s a real sense of

Whitehead Institute and Harvard researchers have developed Perturb-Multi, a powerful new approach that simultaneously measures how genetic changes, such as turning off individual genes, affect both gene expression and cell structure in intact tissue.

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

Super exciting work from Katie Galloway

Delighted to bring gene circuits into a wide array of primary cells where they can be used for safe, effective gene therapies. 🧵 (1/n) Tremendous work by lead author Kasey Love to dig into the details of these systems and figure out how to get these to work well! Original

Daša Lipovšek expanding today's discussion to include miniprotein radioconjugates, which link target-binding proteins with radioisotopes that can kill cells or be detected with imaging devices. This facilitates greater targeting and functionality. Koch Institute at MIT #KIsymposium

Congratulations to Barbara Imperiali, the Class of 1922 Professor of Chemistry and Biology, who has been elected as a Fellow of the Royal Society, the United Kingdom’s national academy of sciences. chemistry.mit.edu/chemistry-news…

BioEmu 1.1 predicts functionally relevant conformational changes, including large-scale domain motions and local unfolding events + an increased success rate in predicting the formation of “cryptic” binding pockets.

How Harvard Medical School and industry scientists revolutionized cancer treatment

More functional protein fragments! Further evidence of their important roles in physiology and disease.

Excited to share our lab's first preprint — led by our amazing staff scientist, Naseer Iqbal! We show how the dynamic conformation of an SPFH-family membrane assembly enables bacterial recovery during antibiotic stress. Check it out and enjoy! bit.ly/40EDZMl