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So great to see the fantastic, world-leading science of talented ECRs Monash Biomedicine Discovery Institute & being recognised - both in nature & in The Age. Supporting the next generation of scientific talent in Australia is vital 💪 🔗The Age story (behind paywall): bit.ly/4gS53y4

👇Read on to find out about a fascinating #GPCR acting as a domain of a larger transmembrane protein at the lysosome, important for regulation of #mTOR A wonderful collaboration with @Dr_Ellisdon between MIPS DDB Monash Institute of Pharmaceutical Sciences and Monash Biomedicine Discovery Institute, and a huge effort from our teams

Nature research paper: LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR go.nature.com/3zKOh3i

Excited to share the first project from my postdoc. We studied a ligand bound TRPV1 cryo-EM dataset with state of the art heterotgeneity methods, and developed a way to compare them with a technique we call CryoSVD. paper doi.org/10.1101/2024.1… CryoSVD github.com/flatironinstit…

Exciting session at Crystal35 conference SCANZ with the “rising star awards” starting with Charles Bayly-Jones Monash Biomedicine Discovery Institute 🎉 congrats

In this week’s Editors’ Choice piece, we highlight a study by Bayly-Jones and colleagues in nature, showing that the cholesterol-sensing protein LYCHOS contains a plantlike transport protein domain. Read a summary: bit.ly/3O9VgXa

Highlighted today in Cell a great perspective piece about our recent work on LYCHOS. Arun K. Shukla and colleagues raise interesting points about membrane cross talk! cell.com/cell/abstract/…

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…

The first major body of work from my PhD is now up on BioRxiv! We used AI-designed binders to block the uptake of heme from hemoglobin through ChuA, a heme transporter found in pathogenic E. coli. 🦠🩸🔬 I’m very grateful for my supervisors and all coauthors for their support!

The next nuclear reactor to be prematurely closed in Europe turns off February 15th, in the dead of winter.

Amidst the chaos, here's a belated but exciting highlight on the recent LYCHOS structure by Charles Bayly-Jones Chris Lupton @Dr_Ellisdon Dr Michelle L Halls Roberto Zoncu and I broke down their findings, explored future directions, and tackled the key remaining questions. authors.elsevier.com/c/1kZRC3SNvcEP…