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What’s in cryoprecipitate? FVIII, VWF, Fibrinogen and FXIII Each unit of Cryo increases Fibrinogen by 6-8 mg/dl Hence 10 unit will give a bump of 60-80 mg. If Fibrinogen <100, 10 unit will bump it up to 160-180 provided no ongoing consumption. In DIC recheck. In APL keep>150.

Infection after CD19 chimeric antigen receptor T cell therapy for large B cell lymphoma: Real-world analysis from CIBMTR | Blood Advances | American Society of Hematology ⁦Kitsada Wudhikarn⁩ ashpublications.org/bloodadvances/…

For Residents and Fellows: 1. Hemophilia but Autosomal Dominant pattern, it’s VWD Type N 2. Hepatitis C with limb weakness, Lower extremity rash and AKI, its mixed cryoglobulinemia. 3. Sickle Cell Patient has microcytosis, elevated HbA2 and F: Its Sickle Beta Thal mixed Hbopathy

DIC vs. Primary Fibrinolysis. DIC is fibrinolysis after formation of Fibrin polymer. Both Fibrin Split Products and D-Dimers are elevated. Primary fibrinolysis is before polymerization. So FSP high but D Dimer normal. I saw a patient with snake bite and Primary Fibrinolysis

For Residents and Fellows: 1. Sickle cell physiology with splenomegaly and Proliferative Retinopathy: Consider Hb SC 2. Most Primary CNS lymphomas are Non GCB. If GCB, consider secondary. 3. JAK2, PDL1 and PDL2- All located on the same locus Chromosome 9p24.1. Upregulated in HL.

While taking a Statin, Apixaban, or Imatinib, one should avoid foods that interfere with CYP3A4 like grapefruit. But did you know Seville oranges do the same? Seville oranges are used in Orange Marmalade and some liqueurs. Also used as orange peels in cooking. 👇🏽❌❌

Marginal Zone Lymphomas are sometimes associated with infection. 1. Gastric: H.pylori 2. Ocular: Chlamydia trachomatis 3. Splenic: Hepatitis C 4. Cutaneous: Borrelia burgdorferi

Enjoying, learning. getting amazed by the great works being done at the #CellAndGeneTherapy center Faculty of Medicine, Chulalongkorn U.. Great way to spend a #happy4thofjuly2025. Thank you Chulalongkorn U. for inviting me.

Best part of weekend call is that you never get Monday Blues.

Long-term outcomes of light chain amyloidosis patients receiving heart transplant: A single-center experience - JHLT Open jhltopen.org/article/S2950-…

BK Virus is Bladder-Kidney tropic but the name derived from the initials of the first patient it was seen. Causes hemorrhagic cystitis post transplant. Besides bladder wash, three way Foley, cystoscopic cauterization: Cipro, Cidofovir, Leflunomide, BK CTL can be tried.

EBV related cancer: 1. PTLD 2. NK/T cell lymphoma 3. Some Hodgkin 4. African Burkitt’s 5. 10% Gastric Ca 6. Rare sarcomas 7. EBV+ DLBCL NOS 8. Nasopharyngeal CA Please add if I missed some.

Purple top tubes are meant for drawing CBC. The bottom of the purple top tube is coated with a white residue. That’s EDTA-works as an anti coagulant by chelating out Calcium that’s needed for coagulation. Calcium is integral to coagulation. Calcium is the Clotting Factor 4.

In med school we read Parkinsonism and syndromes were: 1. Neuro degenerative 2. Drugs 3. Toxins like CO or MN 4. Post infectious 5. Structural or traumatic like CTE 6. Genetic or metabolic like Wilson’s 7. Vascular Add CAR T now as a cause. 👇🏽

#Myeloma Paper of the Day: Single-center experience of long-term outcomes of AL #amyloidosis patients receiving heart transplant finds 1-, 3-, 5-, and 8-year survival (87%, 83%, 73%, and 67%) not different vs. non-AL patients (92%, 85%, 79%, 68%): pubmed.ncbi.nlm.nih.gov/40687315/. #mmsm

🧵 Long-term Outcomes in AL Amyloidosis Patients Undergoing Heart Transplant 1/🫀💡 Think AL amyloidosis = poor heart transplant outcomes? Think again. A new single-center study from Houston Methodist (2009–2023) shows comparable survival in AL patients vs non-AL heart transplant