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Why are protein lifetimes in mammalian tissues important for understanding the functioning of biological systems? Read about this and more in the opinion that I co-wrote with the SavasLab Trends in Biochemical Sciences #proteomics #proteostasis #ProteinTurnover cell.com/trends/biochem…

If you attended #SfN22 San Diego last week, did you get covid there? (23,800+ people, most not wearing masks, so this is a useful test case). Pls RT. #neuroscience

📢 Join Janelians Gabriela Michel, Misha Ahrens & Emmanuel Marquez-Legorreta, and experts from around the world, at this two-week, entry-level course for African students and young researchers. 🗓️ Apply by Feb. 15: trendinafrica.org/computational-… TReND in Africa

Whole mouse body antibody staining using a cyclodextrin to remove cholesterol and better permeabilize tissues biorxiv.org/content/10.110…

How useful is a connectome? We show that you can predict quite a bit about the neural activity of a circuit from just measurements of its connectivity. Led by star graduate student Janne Lappalainen, collaboration with Jakob Macke. #connectome biorxiv.org/cgi/content/sh… 1/n

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30-COLOR DNA-PAINT at sub-15 nm RESOLUTION. I am overly excited to tell you about "Spatial proteomics in neurons at single-protein resolution" our latest work led and developed by my brilliant and amazing colleague Eduard Unterauer. 1/8 biorxiv.org/content/10.110…

We then focused on neurons together with Eugenio F. Fornasiero and Felipe Opazo. SUM-PAINT resolves Spectrin rings, Clathrin pits, synapses, neurofilament fibers, and trans-synaptic nanocolumns (with molecular matches at the single-protein level) at the highest resolution. 5/8

Protein profiling for several target in neurons at ~15 nm resolution: a wonderful collab. with Ralf Jungmann's lab. Hats off to everyone who made this possible, including Eduard Unterauer Kristina Luciano A. Masullo carsten marr Felipe Opazo #synapse #microscopy biorxiv.org/content/10.110…

For the past decade, Luke Lavis (@rhodamine110) and his team have been creating and perfecting the Janelia Fluor dyes. Now, they’re working with biologists to design dyes for specific biological applications. janelia.org/news/next-gene…

Thrilled to share a new teal Ca2+ indicator! #TGECO is a blue-shifted biosensor with high SNR & enhanced 2P absorption, great for #multiplexing in vivo!🧵 See preprint below⬇️ biorxiv.org/content/10.110… @Campbell_FPs Yi (Eason) SHEN 沈溢 Kaspar Podgorski Allen Institute HHMI | Janelia U Calgary

Neuronal activity modulates the incorporation of newly translated PSD-95 into a robust structure as revealed by STED and MINFLUX biorxiv.org/cgi/content/sh… #biorxiv_neursci

E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵

🥼 Janelia researchers led by Boaz Mohar (@[email protected]), Nelson Spruston, Luke Lavis & karel svoboda Allen Institute have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 janelia.org/news/new-imagi…