🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

pubs.acs.org/doi/full/10.10…

Here's the most recent picture of the Gellman group, featuring Sam (of course), post doc Ariel, graduate students, as well as a few diligent undergraduates that are working closely with us over the summer. #bondamidebond #gellmangroup

Can't wait to see our neighbors (literally) do some awesome chemistry!

Congratulations to Sam!

Check out our lab's newest publication on the impact of backbone modification on PTH (1-34)'s signaling profile!

Here is another recent publication from our lab and collaborators on PTHrP (1-34) hormone. Both backbone and side chain modifications were implemented to improve the affinity between PTHrP and PTHR1.

Our lab's most recent publication explores a new strategy, amide-to-thioamide replacement, for modifying short peptides that serve as MHC-I displayed antigens with the goal of enhancing the immunological function of these peptides. pubs.acs.org/doi/full/10.10…

Congratulations to Kyle and Rylie!

In a collaboration with Ying Ge Research Lab, we characterized the phosphorylation status of GIPR followed by activation of the receptor. Congratulations to Kyle, Rylie, and Samantha!

A synthetic peptide developed by Samuel Gellman, Kyle Brown and Rylie Morris could lead to a powerful new drug to treat type 2 diabetes and obesity. Gellman Lab UW-Madison Chemistry UW-Madison L&S #WisconsinInnovates warf.org/videos/potent-…

Our first collaborative work with Sam Gellman’s lab Gellman Lab UW-Madison Chemistry. Congratulations to all the authors! This article is also part of the virtual special issue for the Greg Voth Festschrift! pubs.acs.org/doi/10.1021/ac…

Great Streck Award visit from Sam Gellman Gellman Lab UW-Madison Chemistry – The evolution of hybrid beta-peptide foldamers to uncover, modulate and bias GPCR function! Great interaction with Nebraska Chemistry Community & @Berkowitzgrp James W. Checco group @unlresearch Nebraska CAS #GBR

Throwback to yesterday's WHIRLWIND Hirschmann award symposium honoring Arora Lab @ NYU, feat. Gellman Lab, Monika Raj, Kent Kirshenbaum, Bill DeGrado, Ronald T. Raines, Christina Schroeder, @AnnaMapp, with special guests Phil Dawson and Jay Schneekloth!

A News & Views by Martin Zacharias and Sebastian Springer highlights recent work J. Am. Chem. Soc. on the design of peptide vaccines. Free to read link at rdcu.be/dE22d and link to the original article pubs.acs.org/doi/10.1021/ja…

A synthetic peptide developed by Samuel Gellman, Kyle Brown and Rylie Morris could lead to a powerful new drug to treat type 2 diabetes and obesity. Gellman Lab UW-Madison Chemistry UW-Madison L&S #WisconsinInnovates warf.org/videos/potent-…

New paper: The Wisconsin Photoreactor Platform in chem. ed. We exploit an energy transfer photocatalyzed E→Z isomerization (pioneered by GilmourLab) to build an adv. org. chem. lab experience. This ACS Editor’s Choice paper is open access. Check it out! pubs.acs.org/doi/10.1021/ac…

A New Mechanism for Formation of Glycine from Glyoxylic Acid: the Aza-Cannizzaro Reaction (Samuel H. Gellman and co-workers Gellman Lab) #OpenAccess onlinelibrary.wiley.com/doi/10.1002/ch…

Our work on bifunctional organocatalysis of aldol reactions by flexible dihydrazides is out in J. Am. Chem. Soc.. We find that hydrazide units connected by long, flexible linkers offer significant rate enhancement relative to monohydrazides. doi.org/10.1021/jacs.4…

We are pleased to share a catalytic and enantioselective approach to the synthesis of chiral 7- & 8-membered rings. Read more about Nicolò’s recent work on John Callahan Nicolò Tampellini pubs.acs.org/doi/10.1021/ja…

Molecular and structural insights from exploring the impact of spatiotemporal signaling profiles following GLP-1R activation PNASNews pnas.org/doi/10.1073/pn…