"While several medications [for child obesity] demonstrated greater weight loss than placebo, the totality of the evidence was found to be inadequate. An important limitation of the pharmacotherapy studies was that there was only a single trial for each effective medication (ie,

NCI: Large analysis finds that for healthy adults, taking multivitamins daily is not associated with a lower risk of death. medicalxpress.com/news/2024-06-l…

Don't know if others were aware of the passing of James C.Coyne a frequent poster here and elsewhere. Here is his obit legacy.com/us/obituaries/…

My polemic in Nature on probability has attracted some attention nature.com/articles/d4158… - you should be able to download from here rdcu.be/d41qA

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (Altos Labs 🤑), why the epigenome changes with age at all is unclear. In Nature Aging today, we suggest a potential driver: somatic mutations.

Relapse prevention isn’t just humane; it’s economical. Let’s shift focus to long-term mental health care.

Bipolar disorder and artistic temperament: Mechanisms Linking Creativity and bipolar disorder. sciencedirect.com/science/articl…

Anti-psychiatry has plenty of brilliant minds who can tear the field apart with philosophy, rhetoric, and clever arguments. But none of that survives a single shift in a psych ER.

"A GO term analysis? how is this helpful?"

Misdiagnosed as having depression? You’re not alone. Many with bipolar are first told it’s depression and spend years on the wrong treatment​. It’s frustrating, but you're not alone. Keep pushing for a proper psychiatric assessment – the right diagnosis is the first step toward

Louella Vaughan Ash Paul Yug Shankar UMAPs.org.uk NHS England PA Stephen Nash The Leng review GMC Adam Skeen Adele Drew-Hill The BMJ There’s a real loss, I feel, in teaching medical reasoning at an early stage when you substitute with non-doctors, who do not possess medical reasoning. You need that training to be able to link science back to the patient to start at the foundations of the degree.

Viewpoint: Target trial emulation can improve observational study validity by applying randomized trial design principles, but it is not a substitute for randomization. ja.ma/4jJzoA1

Only 10-30% with bipolar take lithium, but 90% of experts in new survey rank it their top choice: pubmed.ncbi.nlm.nih.gov/40505671 Why? Better long-term outcomes, and addresses underlying causes of the disorder in new review by R Post et al: pubmed.ncbi.nlm.nih.gov/40505671

Esketamine nasal spray as a monotherapy improved depressive symptoms in treatment-resistant depression (TRD) compared to placebo. ja.ma/4mJgwm3

Viewpoint: Patients with psychotic conditions often wish to stop antipsychotics, suggesting a shift to shared deliberation for collaborative management of associated risks. ja.ma/3UXUX55

Swedish authorities are considering requests for “de-diagnosis services” for autism and ADHD from a new patient group: adults who no longer want their diagnosis bmj.com/content/390/bm…