🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…

Great article about the bridge RNA discovery from Evan DeTurk! Very grateful that he took an interest in it and reached out to interview me and Nicholas Perry. berkeleysciencereview.com/article/2025/0…

Out now in Molecular Cell: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-cell… Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein? A 🧵

Massive effort lead by the amazing fabienne.benz to discuss the present and future of CRISPR-based antimicrobials ⚡

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

biorxiv.org/content/10.110…

"Does it work in human cells?" is a question I've gotten a lot this past year. Excited to share our latest work on bridge recombinases! It's been a lot of fun to lead this team effort. If you are excited to hear more, join for my thesis defense tomorrow at 3pm PT. Links below:

Do you need programmable DNA insertions? Excisions? Inversions? Nicholas Perry led the team that proved you can now do it all with one system, bridge recombinases, in human cells! It has been a true pleasure working with him and the team on this amazing project!

With a bit of a lag for X... 🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 science.org/doi/10.1126/sc…

Come work with me, Martha Clokie ,Spyridon Megremis, PhD (he/him)🇬🇷🏀☘️🎧 in the Becky Mayer Centre for phage research on the isolation and genomes sequencing of 1000s of phages for a biobank. jobs.le.ac.uk/vacancies/vaca…

Just in time for finals 🙇‍♂️: a bacterium designed to live in your gut and keep you performing well with little sleep. Rachel Hopton, Ph.D. Daniel Pascal Brandon Fields #microbiome #synbio #biotech #AirForce MIT Dept of BE Massachusetts Institute of Technology (MIT) pubs.acs.org/doi/full/10.10…

Does anyone have a Col156 plasmid (small, high-copy, not co-integrated on an F) handy they’d be willing to share?

🦠💐🦠 人生一報目のプレプリントが公開されました！ I'm thrilled to share the first-first preprint in my life! Host range and ARG dissemination are shaped by distinct survival strategies of conjugative plasmids biorxiv.org/content/10.110… (1/🧵, Japanese follows English) 💐🦠💐

Proud of our PhD student Ryuichi Ono! His undergrad research UTokyo | 東京大学 just produced his 1st 1st-author paper on how plasmid survival tactics dictate host range & spread of antibiotic resistance genes. The skills he gained are already powering grad-school projects in our lab!

Life-Stage Transitions Drive Distinct Gut Viral Communities in Dairy Cattle biorxiv.org/content/10.110… #biorxiv_micrbio

Despite the chaos and turmoil, our lab is blessed to have 3 new postdoctoral fellow openings and we would welcome scientists interested in: - combining single-molecule studies with cryo-EM - developing new protein design tools using bioinformatics and structure-based tools -

🚀 Excited to release BoltzDesign1! ✨ Now with LogMD-based trajectory visualization. 🔗 Demo: rcsb.ai/ff9c2b1ee8 Feedback & collabs welcome! 🙌 🔗: GitHub: github.com/yehlincho/Bolt… 🔗: Colab: colab.research.google.com/github/yehlinc… Sergey Ovchinnikov Martin Pacesa

1/6 🧬📊 Curious about the buzz around NLP in biology? Feeling overwhelmed by the rapid developments? We've got you covered! Our review on NLP applications in genomics, by the wonderful Ella Rannon, is now out as a pre-print! #NLP #Bioinformatics arxiv.org/abs/2506.02212