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Can you do high-throughput functional screens directly on patient-derived macrophages? We did it for glioblastoma (GBM)! Thrilled to finally share our latest work from the Weissman and Fattahi labs, now on bioRxiv: biorxiv.org/content/10.110…

Congrats to Stephen Hauser, MD, for winning the Breakthrough Prize for identifying the cause of MS. Hauser's work in ID’ing B cells as the culprit, led to therapies enabling most patients to live free from disability. tiny.ucsf.edu/u2Guqf

CHOIR is now online Nature Genetics! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! nature.com/articles/s4158…

Happy to see my main PhD work in the Fleischmann lab at Brown University Carney Institute for Brain Science published in Nature Neuroscience! -Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution nature.com/articles/s4159…👇🧵

Check it out! Telomere-to-telomere ape genome assemblies reveal new biology & insights into evolution: rdcu.be/eg47u Nature News: nature.com/articles/d4158… Nature Podcast: nature.com/articles/d4158… DongAhn Yoo Evan Eichler UW Genome Sciences HHMI

Excited to share our latest manuscript, a collaboration with Justin Perry - Perry Lab led by Weill Cornell Medicine neuroscience PhD student Ann Kabuki Baako. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation. biorxiv.org/content/10.110…

Excellent study from Gaurav Singh Rathore using stem cell-derived neural tube models to study regionalization and cell fate: biorxiv.org/content/10.110…

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

Postdoc positions available in my lab Karolinska Institutet - exciting science and fantastic environment. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. shorturl.at/sj2YE

Dear colleagues and friends, please join to Celebrate the life of Atul Butte on Saturday at 10am. Co-hosted by @ucsf, Stanford University Harvard University

Last year, we posted a preprint providing the first genetic evidence that the Harbin skull likely belonged to a Denisovan: biorxiv.org/content/10.110… Today, DNA evidence provided the final proof: …encedirect-com.ezproxy.weizmann.ac.il/science/articl…

Our ENS is vital to gut-brain health. When it breaks down, so does health. Treatments? Almost none. Access to functional human enteric neurons at scale powers research, disease modeling and therapeutic discovery. Grateful to everyone who made this possible.nature.com/articles/s4158…

📣 Our protocol to generate brain #organoids from #StemCell derived Single Neural Rosettes 👇

Thrilled to share this amazing team effort, huge thanks to Arnold Kriegstein and everyone who made it possible! Big congrats to Clara Siebert, Dr. Yuejun Wang, MP Pebworth . Grateful to lab members for the insightful discussions and support throughout!🥂❤️ nature.com/articles/s4146…

It's finally out! Thankful for my mentor Arnold Kriegstein and all collaborators🙏 nature.com/articles/s4146…

We present the MIND model — Multinodal Induction–Exclusion in Network Development — in which S–A patterning is regulated by fronto-temporal “association” and central “sensorimotor” transcriptional identity programs

Now out in #NatureNeuroscience: new paper from our lab — "Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice." Congrats to first authors Ann Bright, Yana Kotlyarenko, Florian Neuhaus! nature.com/articles/s4159…