Delighted I received more immunotherapy (iv infusion) after radiotherapy y’day. All went incredibly smoothly- I can’t thank everyone enough for all they are doing to help me on this novel treatment journey esp Professor Georgina Long AO (Bluesky @gvlongphdmd). Fingers crossed no major speed bumps in coming weeks!

Vale Justin Yerbury. Thank you for all you strived for and achieved for MND research.

A proteome-wide study of more than 10,000 middle-aged adults identifies 15 proteins linked to a higher risk of #dementia and #AlzheimersDisease 25 years later.  Learn more in Science Translational Medicine: scim.ag/3y4

Landmark day 4 me today: half way through daily radiotherapy course (3 weeks to go)! CT scan images mapping my radiotherapy field show how precisely targeted it is (highest dose in yellow circle, less in blue, least in red: like contour lines on a map!).

Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model: Cell Reports cell.com/cell-reports/f…

Molecular architecture of the developing mouse brain nature.com/articles/s4158…

cGAS–STING drives ageing-related inflammation and neurodegeneration. Great paper nature nature.com/articles/s4158…

Silencing a liver enzyme suppressed amyloid and tau pathology in the brains of two #alzheimersdisease mouse models. Shenzhen University ow.ly/y2E050PrgAE

All academics--not just scientists--should support researchers like @edwardcholmes & Kristian G. Andersen, who are currently under a neo-McCarthy-esque attack. The attacks on individual scientists are terribly concerning. Even more concerning is the broader undermining of shared truth

I’m blown away & incredibly proud to hear that, based on world 1st scientific data from unique & riskier open craniotomy biopsies taken pre/post neoadjuv combi #immunotherapy for my #glioblastoma (GB), biopharma companies r looking to expand drug development programs into GB

New research describes a pathway by which cardiac disease leads to immune-mediated sympathetic denervation of the pineal gland and a subsequent decrease in circulating melatonin, causing sleep disruption. 📄: scim.ag/3Ck #SciencePerspective: scim.ag/3Cl

Reactive astrocytosis in #Alzheimers disease dominated by downregulation of homeostatic transcriptome. Beautiful single nucleus RNAseq pseudotime analysis by David Dai in our lab. doi.org/10.1186/s40478…

Whilst I’m absolutely thrilled & blown away to receive Lifetime Achievement Award from Society For Melanoma Research, more importantly this is more reflective of the amazing multidisciplinary research team & it’s incredible work that Professor Georgina Long AO (Bluesky @gvlongphdmd) & I lead Melanoma Institute Australia! Sydney Local Health District University of Sydney

The BTRC team gave the #City2Surf a red hot go yesterday! 🏃🧠👏

New study by Tony Wyss-Coray and team finds brain-wide gene signatures of aging in glial cells. The research, partly supported by our AHA-Allen initiative, also found that glial cell aging is accelerated in white matter and not all regions are equally impacted. cell.com/cell/fulltext/…

A new brain mapping approach reveals that volume changes in psychiatric illness occur in variable locations across individuals, but these differences often aggregate within common brain systems. The findings are published in Nature Neuroscience. go.nature.com/45brxEd

Delighted how well things are going so far 4 my #glioblastoma Rx. #Radiotherapy hasn’t knocked me about much (complete 6 wks daily Wed). More combi #immunotherapy next Tues. Incredibly grateful 4 massive support I’m receiving from family/friends/colleagues/communities worldwide!

TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain | Science Advances science.org/doi/10.1126/sc…

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Very pleased to win the Molecular Horizons @ UOW publication of the month award for March 🥳 This paper is one of my PhD thesis chapters looking at how nNOS is increased in the #alzheimers brain and impacts neuronal calcium signaling. Check it out 👉 liebertpub.com/doi/10.1089/ar… UOW UOW Research