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CHIP stands for clonal hematopoiesis of indeterminate potential. But it's no longer "indeterminate," as exemplified by this report, and needs a new abbreviation Nature Medicine by Caitlyn Vlasschaert Alex Bick and colleagues nature.com/articles/s4159…

Excited to share our paper Laventa Obare Tecla Mtui Temu, MD, Ph.D @VUMC_heart Vanderbilt PSTP/Harrison Society @VI4Research , "Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease" now published in Circulation Research ahajournals.org/doi/10.1161/CI…

Congratulations Dr. Tara Mack on a spectacular PhD defense! Your science, mentorship and leadership in the lab and across campus is an inspiration. It has been such a privilege to learn together the past 3 years. @VUMCgenetics Vanderbilt School of Medicine Basic Sciences Vanderbilt School of Medicine Vanderbilt University Medical Center

Congratulations to Alyssa Parker from our group on receiving the 2024 Basic Sciences Dean's Award!

We are excited to share our new preprint “Variance quantitative trait loci reveal gene-gene interactions which alter blood traits”! medrxiv.org/content/10.110…. Thread below 🧵 1/n

.Alex Bick, a physician-scientist at Vanderbilt University Medical Center who is known for his research on the genetics of blood disorders, has been named director of the Division of Genetic Medicine. Congrats, Dr. Bick! @VUMCgenetics @VUMC_Medicine bit.ly/3TRcY53

Congratulations to STAT 2024 wunderkind Caitlyn Vlasschaert! Caitlyn has authored more than two dozen papers with our group in the past two years on #CHIP, firmly establishing it as a risk factor for kidney disease and beyond. @VUMCgenetics statnews.com/meet-the-2024-…

Just how many diseases can you identify with a good old 12-lead #ECG? NEW npj Digital Medicine, co-led w/ Sam Freesun Friedman, RVpacing & xwang, we use an autoencoder to map ECG to phenome, finding associations btwn ECG & >600 conditions Broad Institute ML4H Mass General Heart LINK⬇️

Alex Reiner Fred Hutch Cancer Center, Alex Bick, and I are excited to share our new preprint, “Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women” doi.org/10.1101/2025.0… 1/n

Two VUMC physician-scientists named to medical honor society news.vumc.org/2025/01/14/two… Congrats to Alex Bick and Vanderbilt PSTP/Harrison Society alum jon kropski on this well-deserved honor!

Our latest review, spearheaded by Amanda Doran, on the Bone Marrow Niche in Cardiometabolic Disease is out in Circulation Research AHA Research IU School of Medicine Department of Medicine VUMC Research HHP at UH Meena Madhur @HeatherCaslin Brett Heimlich Jonathan Brown Ferrell Lab ahajournals.org/doi/10.1161/CI…

This is a remarkable feat on so many levels. *Massive* congrats to Kiran Musunuru (former Circulation: Genomic and Precision Medicine EiC & Sek Kathiresan MD lab co-alum) Sarah Grandinette Rebecca Ahrens-Nicklas & team! nejm.org/doi/full/10.10… NEJM (coverage nytimes.com/2025/05/15/hea… The New York Times by Gina Kolata)

We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)

New preprint: teaching single-cell foundation models to learn from perturbations in collaboration with Ravi Madduri & RUNX1 Research Program supported by CZI Science. Closing the loop identified a target for RUNX1-FPD now in Ph2 trials 🔗biorxiv.org/content/10.110… 🧵by @yash_persh👇