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Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with Jonathan Weissman's Lab's Edwin Neumann & Tessa Bertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/sc… Blog: cureffi.org/2024/06/27/int…

This. is. NOT. yet "another" gene therapy paper. The patient's name is Michael, he is Terry Pirovolakis's son, and if you google that name and learn what it took to make this happen (watch a talk by Terry) - you'll read this paper in an entirely new light.

Check out our latest paper showing that HLTF removes Cas9 from DNA, explaining phenotypic differences when using the two Cas9 nickase variants. Important for gene editing! Thanks to Giordano Reginato & Rosaria and @MartinJinek Taekjip Ha andre nussenzweig lab nature.com/articles/s4146…

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

Is anyone interested in coming to work with the amazing crowd at the Cuella Martin lab and our cool projects? An RA position will open soon, stay tuned!

The Dept. of Molecular Biology at Princeton University invites applications for a tenure-track faculty position at the Assistant Professor level. We seek a colleague who will build a world-class research program in cell biology. For details and to apply: princeton.edu/acad-positions…

Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.

No one can take apart a complex dataset like Thomas Norman!!!

Chromatin scientists, want to reorganize genomic loci as you wish? Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/…

Thrilled to share my lab’s latest work, out recently in Mol Cell, on a role for HLTF in G4 resolution. Led by the amazing Gongshi Bai with essential contributions from @davidcortez, Brandt Eichman, Cejka Lab and The Boulton Lab. See: authors.elsevier.com/a/1jbBg3vVUPRm…

🚨 TENURE-TRACK Faculty Opportunity The Genome Integrity Program UMass Chan Medical School umassmed.edu/genomeintegrit… Join us exploring DNA replication/repair with Core services supporting your cutting-edge research. 🔗 Learn more: academicjobsonline.org/ajo/jobs/28037 #Genomics #FacultyJobs #Research #Science

Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇 crick.ac.uk/careers-study/…

Excited to share our preprint of my PhD work in the Jasin lab Memorial Sloan Kettering Cancer Center! We find that CRISPR Cas9-induced DNA double strand breaks, even at a single locus, cause large-scale loss of heterozygosity. biorxiv.org/content/10.110…

Excited that our work on transcription-coupled DNA repair is now published Cell! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltext/…

New paper with Goran Kokic and Jesper Svejstrup Laboratory in Cell Press! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by diana van den heuvel , Marta Rodríguez-Martínez, Paula van der Meer! cell.com/cell/fulltext/… 1/6

Thrilled to see our work out in Nature Methods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.

So proud of this effort from the lab!

Present your CRISPR research on a global stage!🧬✂️ Share your #GeneEditing insights with peers interested in learning more about applying #CRISPR approaches for modulating the genome at scale. #CRISPR25 ⏰Abstract deadline: 4 February 📎 Find out more: bit.ly/3Amz34N

We enjoyed a great round of talks by Alberto Ciccia (Columbia), Lee Zou (Duke), Dr. Agnel Sfeir (MSKCC), and Ranjit Bindra,MD/PhD (Yale), plus our trainees Arindam Datta and Azrin Jamalruddin at yesterday’s PCGI Mini Symposium on "Targeting the Damage Response"