🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

What does the circulating proteome teach us about common heart diseases? Thrilled to share our analysis identifying new biomarkers, drug targets, and prediction models for these conditions. Co-led by Ashley Pournamdari, with Michael Honigberg, MD, MPP and Pradeep Natarajan nature.com/articles/s4416… (1/x)

Excited to share our latest in Nature Cardiovascular Research led by ⭐️ Art Schuermans w/ Pradeep Natarajan Open access paper here: nature.com/articles/s4416… Great thread from Art Schuermans below 👇

(1/10) Check out our new paper in Nature Communications! “Non-random mating patterns within and across education and mental and somatic health”. In the paper, we study partner similarities before they (were likely to have) met. nature.com/articles/s4146…

Terrific holiday party / “Yankee swap” 🎁🔄🎁 with Michael Honigberg, MD, MPP Akl Fahed Zhi Yu Pradeep Natarajan labs 🎅 🎄 Mass General Heart Broad Institute

Excited to kick off 2025 with our latest publication! We've developed TGFM, a new statistical method for identifying the causal tissue and gene underlying GWAS disease loci—providing new insights into the biology behind GWAS signals. nature.com/articles/s4158…

Delighted to share our study by Sarah Urbut with Akl Fahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events ahajournals.org/doi/10.1161/CI… Circulation: Genomic and Precision Medicine

Our first multi-national GWAS on income is out in Nature Human Behaviour 🧬💰 - 162 loci (88 novel) - significant heterogeneity between countries - significant heterogeneity between men and women - unique non-education income effects Open Access Link: nature.com/articles/s4156…

Learn about polygenic risk score research from the best - very fortunate to work with Yunfeng Ruan🌻 #StandWithUkraine🌻 in my group Broad Institute cc PRIMED Consortium BroadMPG AHA Council on Genomic and Precision Medicine

📢Out now! Xihao Li, Pradeep Natarajan, Zilin Li, Zhonghua Liu, Xihong Lin, and colleagues from NIH NHLBI present a framework for functionally-informed multi-trait rare variant analysis of biobank-scale sequencing studies. nature.com/articles/s4358… 🔓rdcu.be/d82Fx

We're thrilled to share our latest publication, A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies, in Nature Computational Science. Sincerely thanks to Xihong Lin for incredible mentorship, Zilin Li, Zhonghua Liu, Pradeep Natarajan, Dr.

Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w Aniruddh Patel demonstrates how successive score integration can improve accuracy & stability nature.com/articles/s4146…

Our new exciting study empirically shows that integrating PRSs from different methods and contexts not only can improve accuracy but also generalized stability! Helpful in the era of plethora of new PRS methods being developed!

📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬medrxiv.org/content/10.110… 🧵👇 (1/n)

Did you get a chance to read the thread on our new Nature Human Behaviour paper on SES yet? If not, don't worry, I have something better for you! Check out this comic by the amazing Lizah.PsD - LizahAart on 💙☁️ The complete comic here: communities.springernature.com/posts/are-we-b… You can also scroll this thread 👇🏾

I am excited to present our new study out in Nature Medicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the Tony Wyss-Coray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

Our latest on 🫀 health, 🧬, & 🤰 now out in JACC Journals #JACC ⬆️ 1st-trimester CV health strongly associates w/ ⬇️ risk of hypertensive disorders of 🤰 (HDP) overall & across levels of HDP 🧬 risk ➡️ opp to prevent 🤰 complications & long-term CVD jacc.org/doi/10.1016/j.…

Very excited to share our preprint led by Michael Levin Satoshi Koyama Jakob Woerner & with Scott Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! medrxiv.org/content/10.110… medRxiv [1/3]

Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. sciencedirect.com/science/articl… JACC Journals #JACCAdv

We have received over 40 registrations and 7 scholarship applications. If you are interested in this opportunity to learn computational methods in genetics and genomics, register now to secure a position! Scholarship application is due in 1 week. Registration is due in 1 month.

🚨 Excited to share our new manuscript in @circAHA led by Tiffany Bellomo and team. We evaluated lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression in UK Biobank. 👉 doi.org/10.1161/CIRCUL… 🧵1/6