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LHCH thoracic audit day today. The brilliant and entertaining Prof Ottensmeier from University of Liverpool gave an inspiring talk about immune therapies in #LungCancer and #Covid_19. Really fired me up for more surgical research.

New paper published in International Journal of Cancer analyzing immune checkpoint expression on different immune cell subsets during curative treatment of head and neck squamous cell carcinoma. dx.doi.org/10.1002/ijc.33… #GRK2254 #ImmunoChatter #cancerresearch #hnscc DFG public | @[email protected] Cancer Research Institute

A massive single-cell #RNA sequencing analysis of 80,000+ virus-reactive killer T cells from #COVID19 patients revealed these T cells vary substantially in exhaustion levels depending on disease severity. From La Jolla Institute, LivUni Institute of Translational Medicine: fcld.ly/47q7ald

Joe Sacco, clinician scientist just gave a wonderful talk on his work in immunotherapy in uveal melanoma. Great work, Joe

eur03.safelinks.protection.outlook.com/?url=https%3A%…

And here is the link to the paper: biorxiv.org/content/10.110…

Read this #preprint on Research Square: Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial researchsquare.com/article/rs-337…

acir.org/weekly-digests… our story in T follicular regulatory cells recognised by AICR - very proud

We are very proud to report that our study "Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer" has been published in the Journal for ImmunoTherapy of Cancer.

This study was an important step in our collaboration with Transgene, and an early phase clinical trial of personalised immunotherapy in patients with head and neck cancer. clinicaltrials.gov/ct2/show/NCT04…

jitc.bmj.com/content/10/3/e…

We are super happy that our Nature paper went public yesterday. Please find the open access paper at: nature.com/articles/s4158… we believe that this is potentially a really big step on how to make combination immunotherapy better for more patients.

it is also an amazing team effort: surgical and medical oncologists from our head and neck center, a multi center clinical collaboration with our friends in Poole, Southampton, Glasgow, amazing scientists in the La Jolla institute...

... and preclinical collaboration with teams in UCL, Cambridge, and of course CRUK who funded the clinical trial and the Amgen team who made drug available.

nature.com/ni/journal/vao…