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I'm thrilled to share new work from Elizabeth Gallagher providing new insights into the clearance of damaged lysosomes by lysophagy:biorxiv.org/content/10.110…. Lysosomal health is critical to neuronal health, making this work highly relevant to Parkinson's disease and ALS.

Beyond excited to share my thesis work characterizing the role of p62 phase condensates in lysophagy! biorxiv.org/content/10.110…

Happy to share our paper Scientific Reports. We describe and characterise a novel iPSC microglia-motor neuron co-culture, which can be used for #MND #ALS research. Special thanks to Kaitlyn Wade-Martins Lab for a great collaboration. Nuffield Department of Clinical Neurosciences Kavli Institute for Nanoscience Discovery, Oxford nature.com/articles/s4159…

Our first preprint is out from the Stavoe Lab! with heathertsong and Erika Holzbaur-Howland Aging Differentially Affects Axonal Autophagosome Formation and Maturation biorxiv.org/content/10.110…

Excited to see this online!

Happy to share this review on LRRK2 and intracellular organelle dynamics Journal of Molecular Biology. Enjoy! authors.elsevier.com/a/1gbUA54HFRkdU

A threat to all scientists in Germany, particularly to postdocs: On 17 March the German Ministry of Science released a paper on the planned amendment of the German Act on Temporary Scientific Contracts. Contracts for postdocs shall be limited to 3 years - then you are out!.....

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes dlvr.it/SnPb92

Very happy to share our latest work on LRRK2 (and my first paper as co-last author). We find that LRRK2 mutations disrupt a regulatory balance between LRRK2, PPM1H, and ARF6, causing impairment of axonal autophagosome transport. Dan Dou Erika Holzbaur-Howland Universitätsmedizin Göttingen (UMG)

📣Take away: OPTN does it differently! 🚨Thrilled to share my latest #notacover piece prepared for Thanh Nguyen Michael Lazarou @martens_sascha mito911 on #unconventional #OPTN-mediated #PINK1/#Parkin #mitophagy! sciencedirect.com/science/articl…

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors biorxiv.org/content/10.110…

My last paper from grad school is in press! Please check it out--thanks to good suggestions from reviewers and a lot more work, it has a significantly more detail than the BioRxiv version Erika Holzbaur-Howland Journal of Cell Biology doi.org/10.1083/jcb.20…

What regulates the transport of autophagosomes along the axon? @sydneycason & Erika Holzbaur-Howland show that mature axonal autophagosomes are transported by the #microtubule motor #dynein, activated by JIP3/4, & regulated by ARF6 & RAB10 bit.ly/3MrP5Nw #Neuroscience #autophagy

Excited that our paper reporting discovery of TMEM55B, a new downstream lysosomal component of the LRRK2 #Parkinsons pathway, has been published. Congrats Prosenjit Pal, Matt T, Yuko Lam, & our fantastic Aligning Science Across Parkinson’s collaborators Suzanne Pfeffer lab ppu.mrc.ac.uk/news/parkinson…

📢 Fully funded PhD position available in my lab in Goettingen, Germany If you are interested in cell biology and the pathophysiology of neurodegenerative diseases, we'd love to hear from you! 📅 Application Deadline: Feb 9th 2024 For more details visit boecker-lab.uni-goettingen.de/wp-content/upl…

Dou, Aiken & Erika Holzbaur-Howland Penn Medicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. hubs.la/Q02qgtts0

So proud of this beautiful new work from Dan Dou, and so grateful to Virginia Lee for inspiring this study!

Congratulations to Erika Holzbaur for securing a $1,000,000 donation to establish a Huntington’s Disease Research Fund. The donation will be used to support Huntington’s research by three postdoctoral fellows for three years in key University laboratories.

Excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons" Now on BioRxiv! biorxiv.org/content/10.110…

My lab is starting at UW-Madison! This is a unique opportunity to contribute to impactful computational neuropathology research in a collaborative environment. Join the Nirschl Lab and help drive discoveries that improve our understanding of neurodegenerative disorders!🧠