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SPACEtomo is officially published! :P nature.com/articles/s4159… I'm so grateful for all the support I received especially from Rado Danev and everyone who shared their data with me! And of course thanks to David Mastronarde and the amazing #SerialEM for making it possible!

Our review on genetically encoded CDK biosensors is finally out in CSF! Take a look! jstage.jst.go.jp/article/csf/ad…

🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬 Please spread the news 🙏🏼 Apply here: mrc.tal.net/vx/mobile-0/... #Postdoc #CryoEM #MolecularBiology #Cambridge

Cryo-EM structures reveal the acetylation process of piccolo NuA4 | PNAS pnas.org/doi/10.1073/pn…

Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. biorxiv.org/content/10.110… #cryoEM #transcription #splicing

🚨Preprint, RT appreciated🙏 Our work ‘Substrate recognition by human separase’ by jun, Sophia Schmidt, Margherita Botto UNIGE_en Université de Genève Molecular & Cellular Biology Dept 🔬 Geneva 🇨🇭 Dubochet Center for Imaging (DCI) and members from the Morgan UC San Francisco and Francis O'Reilly labs is online. 🔗biorxiv.org/content/10.110…

Passionate about structural biology and #biochemistry? Join David Haselbach’s group through the Vienna BioCenter #PhD Program (Vienna BioCenter Scientific Training)! ⏳ Deadline: April 15, apply now: training.vbc.ac.at/phd-program/ 📷Watch David's 'Scientist Snapshot': youtube.com/watch?v=DXTOW3…

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms dlvr.it/TK110b

#NewPaper 🧬 A new review dives into the structural biology of tRNA modifying enzymes. Authored by our scientists led by Sebastian Glatt highlighting how cryoEM & crystallography reveal mechanisms behind key modifications. Read here: shorturl.at/akpeB Uniwersytet Jagielloński

Check out our paper on the cryo-EM analysis of chromatin derived from human cells! We have established a technically accessible method for analyzing the chromatin structure prepared from human cells. onlinelibrary.wiley.com/doi/10.1111/gt…

Our lab collaborated with BYU_BiophysicsGroup to create this important tomogram dataset, which will be a useful benchmark for future machine learning developments in the cryo-ET world.

📣 New in The EMBO Journal : Our researchers lead by Sebastian Glatt , together with @IIMCB_Warsaw, Durham University & Synchrotron SOLEIL reveal how #pseudouridine boosts human #tRNA stability using cryo-EM & modeling. Big leap for RNA-based therapies! Uniwersytet Jagielloński SOLARIS Centre

Check out our new preprint on H3-H4 octasome transcription by RNAPII! We discovered that H3-H4 octasome is transcribed more efficiently than nucleosomes and visualized its transcription process by cryo-EM. #cryoEM doi.org/10.1101/2025.0…

This is the bomb !

New online! DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate bit.ly/42YpnJk

Check out our latest study NatureStructMolBiol: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases:#cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains! ❕Publication: nature.com/articles/s4159… Samuel Maiwald Universiteit Leiden

the first preprint of the lab! So excited! 😎#archaea #cryoEM #chromatin #Asgard

New pre-print! Ryan Kim et al distinguish the roles of the Spindle Assembly Checkpoint as a surveillance pathway only triggered by mitotic errors vs a mitotic timer that is required in every cell division. biorxiv.org/content/10.110…

A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦NatureStructMolBiol⁩ #CryoEM #transcription nature.com/articles/s4159…