🛡️How do macrophages tailor their defenses to different pathogens? Our new paper in @CellSystems combines dense multi-omics time series with high‐content CRISPR screens (CROP-seq) to map the regulatory landscape underlying macrophage immune responses. #Immunity #Screening (1/9)

Just a week or so after the publication of his latest paper, Mohamed successfully completed his PhD yesterday! Congratulations, Dr. Shoeb! Mohamed Refaat Shoeb

Excited about our great speakers at the upcoming St. Anna CCRI Symposium 2026. Come join us!

Join us at the St. Anna CCRI Symposium on Cell Fate in Cancer and Development and meet with top experts! Register now >>> ccri.at/st-anna-ccri-s… 🗓 January 23, 2026 14:00-18:00 📍 Van Swieten Saal, Medical University of Vienna

🎓💛St. Anna CCRI is opening its doors to people who want to explore career opportunities in pediatric cancer research. Whether you are a Bioinformatician, a Master’s, or PhD student, a Technical Assistant, or a Biomedical Analyst – register now >>> ccri.at/careers/

Ctrl-DNA: Controllable Cell-Type-Specific Regulatory DNA Design via Constrained RL arxiv.org/abs/2505.20578

Thank you to Jan Škoda (Masaryk Univ & ICRC Brno) for an inspiring guest lecture on repurposing drugs for mitochondria-targeted therapies in MYC-driven pediatric tumors, highlighting new strategies to overcome therapy resistance in cancers such as high-risk neuroblastoma.

🧬 CAR T cells demonstrate the power of engineered cells as therapeutics. But they fail for most patients. Can we make them better by gene editing? Our paper in nature presents a CRISPR platform for optimizing immunotherapies & discovering boosters of CAR T cell function. (1/13)

New research highlights need for genetic screening in PSCs & adult stem cells. Cancer-related mutations found in mesenchymal (18%) and neural (41%) stem cells. #stemcells #pointmutations ow.ly/QqCv50WZryY Hebrew University ISSCR Cell Press Gairdner Foundation The Hospital for Sick Children (SickKids)

📢 We are recruiting a computational PhD student! Come and join our team at St. Anna Children's Cancer Research Institute CCRI ! 👨‍💻👩‍💻Interested in genomics and cancer evolution? Apply here: ccri.at/working-at-the… #PhD #bioinformatics #computational #cancer #genomics #resistance #pediatric #dataanalysis

🚨 Kidney + AI milestone 🚨 Never been more excited to share!!! We built Nephrobase Cell+, the first multispecies, multimodal kidney foundation model: Trained on ~40M cells Across 4 species (human, mouse, rat, pig) From 5 modalities (scRNA, snRNA, snATAC, CosMx, Xenium) Kidney

My group at St. Anna Children's Cancer Research Institute CCRI is looking for a Master student interested in working with #IPSC stem cells as models for pediatric #cancer. 12 month funded position available. Come join us! ccri.at/working-at-the…

New in Nature Reviews Genetics: my Review on how advanced genomic technologies are redefining cellular reprogramming: mapping trajectories, dissecting chromatin dynamics, + lineage tracing & synthetic circuits to push the boundaries of cell identity. rdcu.be/eLv1Z

Long-term prevention of aneuploidy in human pluripotent stem cells by fine-tuning GSK3 activity biorxiv.org/content/10.110…