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🔬 Scientists explored the specific role of CEMIP in the malignant phenotypes and stemness of colorectal cancer cells. CEMIP restoration reversed METTL3 knockdown-driven alterations in cell phenotypes and stemness. Journal of Gastroenterology and Hepatology | bit.ly/40m3jGC

💡 Scientists provide new insight into the role and mechanism of AXL in regulating #NSCLC cancer stem cell stemness. They also gives a new hint for the relationship between AXL and SCD1. 👉 bit.ly/4ndfPSK

💊 Pharmacological targeting of interleukin-1, JAK–STAT and NF-κB, as well as genetic deletion of Nfkb inhibits Pten-induced cell plasticity and reprogramming in a cellular autonomous manner. Nature Cancer | go.nature.com/40iiIb2

💡 Scientists reveal that TET3 promotes tumor growth and progression in bladder cancer partly through modulation of the stemness pathway, highlighting its potential as a therapeutic target and prognostic marker. 👉 bit.ly/3IleoBC

♻️ Investigators revealed that C1orf50 plays a significant role in the regulation of cell cycle processes and cancer cell stemness, providing a potential avenue for novel therapeutic interventions in #melanoma. 👉 bit.ly/3ZVw4Kl

🧫 Investigators performed an extensive in vitro and in vivo molecular and functional characterization, revealing the pivotal role of the lysine methyltransferase SMYD3 in colorectal cancer stem cell biology. Signal Transduction and Targeted Therapy(STTT) | go.nature.com/3TR2F0f

♻️ Researchers showed that AXL was critical for the self-renewal ability of CSCs. AXL overexpression obviously promoted the self-renewal ability of CSCs and attenuated NSCLC cells' sensitivity to Osimertinib. 👉 bit.ly/4ndfPSK

📢 New in Nature Cancer! A study led by Drs. Alejandro Sifrim and Cedric Blanpain shows that innate immunity and the NF-κB pathway control #ProstateStemCell plasticity, reprogramming, and tumor initiation. Learn more: go.nature.com/40iiIb2

Interested in #LipidMetabolism in cancer stem cells (CSCs)? 🤔 This #review from the lab of Dr. BuHyun Youn at Pusan National University underscores the emerging significance of lipid metabolism as both a hallmark and vulnerability of CSCs, offering opportunities for novel targeted cancer

A new study from researchers at Wuhan Union Hospital identifies MSH2 as an oncogenic factor in #glioma.💡 #MSH2 drives stemness and progression through regulation of the Wnt/β-catenin pathway, and may serve as a potential therapeutic target. bit.ly/3GARw0E

ARID3A is highly expressed in #ColorectalCancer (CRC), but the role of ARID3A in the disease remains unknown. 🤔 A new study suggests that ARID3A inhibits CRC stemness, anchorage-independent growth, self-renewal, anti-cancer drug resistance, and tumor growth.

Researchers in South Korea have identified #myricetin, a flavonol from the flavonoid family, as a promising therapeutic candidate for targeting #LiverCancer stem cell growth and overcoming chemotherapy resistance in #HepatocellularCarcinoma. 📖 Learn more:

🧫 By studying ex vivo cultures of breast cancer patient-derived circulating tumor cells, investigators at Harvard Medical School identified a CDKN1B-AKT1-dependent mechanism controlling entry into a drug-persistent state. 📖 PNASNews | bit.ly/4lqcyya

🧪 Researchers developed a targeted polymer prodrug nanoplatform capable of synergistically inhibiting cancer cell stemness by modulating intracellular metabolism and inhibiting protective autophagy. 👉 Journal of Nanobiotechnology | bit.ly/40X4hcN

🩸 Dr. Snehal Shabrish and team at ACTREC-TMC suggest that cell-free chromatin particles circulating in the blood of cancer patients can transform susceptible somatic cells into cancer stem cells, with the potential to promote metastasis. Scientific Reports | go.nature.com/4kI2yz6

🔑 Scientists introduced a prodrug nanoplatform that overcomes key resistance mechanisms in head and neck cancer by coordinately targeting stemness and inducing dual apoptosis/ferroptosis. Journal of Nanobiotechnology | bit.ly/4m4LnZJ

💡 SPC24 reinforced cell stemness through aerobic glycolysis reprogramming, and SPC24 was modulated by transcription factor E2F7. 💨 E2F7 activates the upregulation of SPC24 in BC, which boosts stemness through aerobic glycolysis reprogramming. 🔗 bit.ly/46UkSBJ

🩸 Scientists demonstrate the critical role of DDIT4 in the stemness of AE9a leukemia cells and suggest that targeting DDIT4 may represent a promising therapeutic strategy for eliminating leukemic stem cells in AML1-ETO leukemia. 👉 Molecular Oncology | bit.ly/4lHvbO6

🔎 Researchers identified a novel role of SRPX mutations in acceleration to stemness and malignant progression, which could provide new targets in improving outcomes of glioma. British Journal of Cancer | go.nature.com/46rwA6U

🧫 A novel STAT3 inhibitor demonstrated potent STAT3 phosphorylation and exhibited nanomolar affinity in binding assays and antiproliferative activity across multiple breast cancer cell lines and selectively suppressed breast CSC self-renewal. 👉 bit.ly/40z0Xof