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Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.110…

Volvo posted a 3 min and 46 second ad on Instagram, shot by Hoyte Van Hoytema, the cinematographer of Interstellar and Oppenheimer. It goes against every single rule you can think about as a social lead. Length. Format. Over-produced. Every comment under the ad said it

Published now in Nat Comms... Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life nature.com/articles/s4146… Jesse Kreger Jazlyn Mooney, PhD

A case study has revealed widespread changes to the maternal brain during pregnancy. This is a milestone in the emerging neuroscience of ‘matrescence’ — the idea that pregnancy is a developmental stage in adulthood nature.com/articles/d4158…

New @nature Our blood tests are interpreted by average reference values. That's missing a lot or rich information! Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults.

In science, we often see weird blips in the data. The question: is it artefact (usually!), or something new & exciting? We don’t always have time to dig deep. Our paper in @nature today came from just such a blip. So don’t ignore the weird stuff. Pull on that thread...

Delighted to share our latest work exploring levels of selection operating during pre-cancerous evolution usng single-cell DNA sequencing of HSCs led by the outstanding gladyspoon cell.com/cell-genomics/…

Delighted to share our work on clonal hematopoiesis #CH out now in Nature Genetics. We revealed ancestry as a risk factor for CH 🧵 AstraZenecaUK Cambridge University nature.com/articles/s4158…

How blood ages - A curious case of mice and men. Our latest study nature published today. Biological processes such as DNA mutagenesis often scale to animal time. Blood stem cells have special evolutionary protection against this. 👉🏽nature.com/articles/s4158…

Delighted to share my PhD thesis work is now published in nature! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynamics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis nature.com/articles/s4158…

Delighted to share a major update on our work investigating age-related deceleration in clonal haematopoiesis. Takehome: Widespread and substantial deceleration in fitness with age! Amazing effort by PhD student Hamish MacGregor 💪 biorxiv.org/content/10.110…

The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our Nature paper: nature.com/articles/s4158…

🚨🚨 Our new manuscript is now available online! Co-led with the awesome Mingxiang Teng Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds medrxiv.org/content/10.110…

The potency of abnormal genetic fusion in chronic myeloid leukaemia in our latest study nature 👉🏽 nature.com/articles/s4158… This cancer is an oddity - one of the few single genetic “hit” cancers, a short trajectory (few years) from start to diagnosis, and explosive growth.

Thrilled to share our latest research out today in nature: “Microbial metabolite drives ageing-related clonal hematopoiesis via ALPK1” nature.com/articles/s4158…

Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today Cell Stem Cell !! An amazing collaboration with AK Eisfeld & Elli Papaemmanuil, PhD & Dan Landau !!! Driven by the impressive Maria Sirenko

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in Nature Genetics 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

EVIDENCE OF SOMATIC EVOLUTION IN tRNA genes!!!! This finding could revolutionize what we know about cancer and somatic evolution in aging. Coming from the wizard of tRNA himself, Lluis Ribas, and genomeologist extraordinaire Fran Supek! biorxiv.org/content/10.110…

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in nature nature.com/articles/s4158…

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. By brilliant Adriana Fonseca ✅Early cancer ✅Methylation drivers ✅Epimutation rates ✅CpG lineage tracing biorxiv.org/content/10.110…