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Today we report new #deeplearning approaches for functional #proteindesign. We use these to generate immunogens, receptor traps, metalloproteins, enzymes, and binder proteins. We validate the designs using in silico and lab tests. science.org/doi/10.1126/sc…

Our Institute was founded ten years ago with a small team and a big vision. Now both are larger than ever! Thank you to everyone who helped make this first decade so much fun. Here's to many more 🎉

protein design

Good stuff! I was glad to hear Carson Gido talk about the revolution Google @DeepMind’s #alphafold has brought to #biotech but how it has limitations, and hear @dawsonwagnertv reflect how #OpenSource facilitates #transparency but cannot alone eliminate #AlgorithmicBias. #ML #AI

there is nothing more swagless than going to grad school

Applications are open for our Undergraduate Summer Fellowship! Students in the US and abroad should apply by Jan 31. From June–August, fellows will conduct research in Seattle with our scientists for 40 hours/week with a $3,000/month stipend. Learn more: ipd.uw.edu/join-us/

The latest work from our group is out in Journal of Biological Chemistry! K-State BMB undergrad and K-State Cancer Research awardee Carson Gido solved 5 crystal structures, and identified two different #neutrophil protease binding sites in a family of #staph immune evasion proteins. jbc.org/article/S0021-…

Ever hear of a single protease inhibitor blocking two different enzymes at the same time? Have a look at our most recent paper in Journal of Biological Chemistry where we show simultaneous inhibition of #elastase and #cathepsin-G by the #staph immune evasion protein, EapH2. jbc.org/article/S0021-…

Congratulations to Nitin Mishra for a successful defense of his PhD dissertation research on #Staph protease inhibitors. K-State BMB

got this one on repeat

#cryoem

Congratulations to Dylan Feist, a JCRC CRA, for being chosen to speak at the NISBRE conference in Washington, DC. #kstate #kstateresearch #kstatecancerresearch #kansas #kansasstateuniversity #kansasstate #thecurestartswithus #cra #kstatecra #nisbre2024

It’s just a tiny bottle.. It probably doesn’t smell that bad Tiny Bottle:

Does anyone know how to get bromophenol blue out of a white t-shirt

Eaps inhibit multiple NSPs simultaneously: 🤯 Read about these very cool and powerful protease inhibitors in the latest paper from the Geisbrecht lab. Very lucky to have been a part of this project!!!!

Same here btw

getting a phd