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Morgan Taschuk We find more significant p-values when the wet lab postdoc does the analysis.

It’s #WorldCRISPRDay so naturally two browsers to catch talks from both Martin Kampmann and Omar Abudayyeh & Jonathan Gootenberg are required 🧬✂️

We have discovered a potent drug that blocks SARS-CoV-2 by a distinct mode of action: 1) EC50 ~ 80 nM by plaque assay; 2) it inactivates viral particles; 3) drug-treated coronavirus no longer binds to host cells. The drug is ethacridine. 1/n biorxiv.org/content/10.110…

Multiplexed activation in mammalian cells using dFnCas12a-VPR biorxiv.org/cgi/content/sh… #bioRxiv

tissue culture and taylor swift is about to be *chef’s kiss*

Absolutely elated to share that I’ll be joining the Tetrad Program UC San Francisco this fall!!!

thinking about my transition to grad school and the first thing I thought about this morning was whether or not I’ll have my own premium snapgene subscription

sci twitter q: what is the best way to manage scientific papers? What are the pros and cons of your pick? I'm a Papers user, but trying to decide if I should make a switch before beginning my phd!

this crossword clue today made me 😠😠

An incredibly sad loss of such an extraordinary woman and advocate. Susan transformed stem cell research and her legacy will continue with those touched by her vision for NYSCF.

excited about multiAsCas12a which we (Chris Hsiung 熊) show enables 6plex CRISPRi functional genomics experiments Arc Institute @ucsf doi.org/10.1101/2023.0…

Our preprint reporting a multiAsCas12a CRISPRi platform for >3plex combinatorial targeting of genes and/or enhancers (including 6plex in high-throughput pooled screens) is now a peer-reviewed publication! go.nature.com/3UTnSXM.

COMET! We generate libraries of combinatorial dCas9-based fusion proteins that modulate transcription at endogenous loci.

Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable

excited about therapeutic biology? consider joining us! job-boards.greenhouse.io/arcinstitute/j…