Paper is out! In context of RCT comparing ketamine vs placebo in depression vs controls, we find ketamine alters resting state ACC connectivity Changes to perigenual & subgenual regions correlate with improvements in symptoms @mehta_mitul72 National Institute of Mental Health (NIMH) nature.com/articles/s4139…

It's #TBThursday! 📢🧠Robin Cash et al. show that neuroanatomically heterogeneous findings in depression can be reconciled from a connectomics perspective and that they localize to clinically meaningful brain networks. #tbt Simon Eickhoff Andrew Zalesky nature.com/articles/s4422…

Our work with Aaron Boes now out at Brain Stimulation! 👏 Using TMS w/ iEEG we show that single pulses evoke spectral responses throughout the brain, including deep brain structures such as hippocampus & cingulate brainstimjrnl.com/article/S1935-… Wu Tsai Neurosciences Institute Stanford Neurology & Neurological Sciences Iowa Neuroscience Institute 🧠⚡️

The presence of a first-degree relative who was diagnosed with depression and did not respond to at least two antidepressants may elevate the risk of suicide mortality and resistance to antidepressant treatment for the patient. ja.ma/4bCDkxO

This is the optimal amount of exercise to improve depressive symptoms. 🧵1/10

Promising results so far for personalised aiTBS in bipolar depression

Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with Corey Keller Angelique C Paulk, now out in Nature Communications, finding that TBS can produce plasticity-like changes in just minutes of stim. nature.com/articles/s4146…

Very excited to share that our 6-site mega-analysis of functional connectivity changes in youth MDD(n=810) is out now in Nature Mental Health (tinyurl.com/mv889hsm) and featured on Research Briefing and the Guardian! Are brain changes in youth MDD the same as those in adults?

JUST OUT in Nature Mental Health: Mapping functional connectivity in youth with depression Largest fMRI sample of youth with MDD curated to date Are depression-related FC changes in youth consistent with those in adults? New work by Connie Nga Yan Tse & Robin Cash & team

Out Nature Neuroscience: Network localization of brain stim targets for PTSD. TLDR: Lesions connected to this circuit REDUCE risk of PTSD in Vets. Also tested with fMRI and TMS. Free link: rdcu.be/dUVTY With Michael Fox Noah S Philip MD David Carreon MD Amanda Arulpragasam Morey Lab

Kudos to Connie for leading this critically important study on intrinsic network-level disturbances in adolescent MDD. Hypoconnectivity of medial structures in the DMN, along w anti-correlations b/t this network and task-positive networks, were robustly linked w depression 🧠

This mega-analysis of 🧠 resting-state functional connectivity in young individuals with major depressive disorder identified several hub regions in DMN and attention network as predictors of depression severity Connie Nga Yan Tse Robin Cash Andrew Zalesky nature.com/articles/s4422…

Where to place an ultrasound transducer to optimally target a specific brain region in a given individual? We developed 𝗣𝗹𝗮𝗻𝗧𝗨𝗦, a tool that helps TUS researchers to quickly and heuristically select the most promising transducer placement(s). A 🧵 on its functionalities.

JAMA Psychiatry Great article on EEG. However IMO there *is* evidence of the utility of fMRI spatial specificity for clinical utility (cf. lots of subcortical in the below). ncbi.nlm.nih.gov/pubmed/30084192 Also, we don't need 40 min of data, network constraints yield highly reliable fMRI in 5-10 min.

TMS is delivered to the DLPFC in depression, aiming to modulate SGC activity But axons linking DLPFC and SGC are absent How then does TMS stimulation modulate SGC activity? Caio's work on TMS propagation in the absence of direct anatomical paths: medrxiv.org/content/10.110…

Please join our full day educational course at #OHBM2025 "How to Use MRI to Optimize Brain Stimulation (tES/TMS/tFUS)" with Robin Cash Desmond Oathes 🧲🧠⚡️👨🏻‍💻 and 10 other great speakers, 24 June 2025. INTF_Network ww6.aievolution.com/hbm2501/Events…

Outcomes for the first 60 MDD patients treated at our clinic Queensland Neurostimulation Centre with robotically delivered & fMRI-personalized rTMS MADRS response=74%, remission=53% for RCT patients EXCITED to see fMRI moving from research to real-world clinical use! karger.com/pps/article/do…

Join our full-day educational course at #OHBM2025 in Brisbane! Learn "How to Use MRI to Optimize Brain Stimulation (tES/TMS/tFUS)". Tuesday, June 24, 9:00 AM - 5:30 PM, Room M2. Explore cutting-edge techniques. ww6.aievolution.com/hbm2501/Events… #BrainStimulation #MRI #Neuroscience #OHBM

Depression often co-occurs with chronic illness, e.g. heart disease, diabetes and obesity, which may be explained by chronic inflammation & metabolic dysfunction. But, what is the course of immunometabolic dysfunction in depression and how that may relate to brain changes?🧵1/6