
Pau Castel
@castel_pau
Oncoprotein aficionado and cell signaling nerd. Interested in cancer and congenital disorders. Assistant Professor of Biochemistry at @nyugrossman
ID: 1233220725894311936
28-02-2020 02:42:04
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1. NEW PAPER! Out latest paper, a joint project between the Cuervo and michele pagano, is out now in Science Advances! If you want to read more about this, please follow the link here: science.org/doi/10.1126/sc…

We are happy to share a paper providing insights into the CDK-independent role of D-type cyclins in regulating DNA mismatch repair. Congratulations to Gergely Rona for the outstanding work. 1/9 sciencedirect.com/science/articl…

Thanks to Biochemical Society for this award!! Very happy that our work is being recognized by amazing colleagues 🧪🧬🔬


Our own Cristina Nuevo-Tapioles representing NYU Grossman School of Medicine and Mark Philips lab at the GTPase FASEB meeting FASEB!!


Finally out! From recent graduate Swati Singh (with help from G Bernal Astrain, AM Hincapie and M Goudreault) - we systemically explored effector binding to a large RAS/RHO/ARF small GTPase library (thanks to Jean-Francois Cote) and validated 39 new interactions! embopress.org/doi/full/10.10…

Check out our latest review regarding the biology of RAS GTPase effectors! It was fun to write this with Alessandro Mozzarelli and Simanshu Dhirendra for Molecular Cell. Bottom line: lots of knowledge on these proteins, but many questions that remain to be answered. cell.com/molecular-cell…





Excited to share our study in Cell on expanding the druggability of GTPases beyond K-Ras and start putting the entire family (150+ proteins) on the map of drug discovery! Kevan Shokat UC San Francisco UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI (1/7) cell.com/cell/fulltext/…


Excited to share our latest research, "Structural Insights into Isoform-Specific RAS-PI3Kα Interactions and the Role of RAS in PI3Kα Activation," now published in Nature Communications 📖 Explore the full article here: nature.com/articles/s4146… @FredNatLab


