🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🔥Excited to share Mădălina Giurgiu Decoil out today Genome Research If you have Nanopore genome sequencing and want to study the structural heterogeneity of ecDNA, try it. Thank you to all the collaborators Cancer Grand Challenges team eDyNAmiC, Max Delbrück Center Charité - Universitätsmedizin Berlin Memorial Sloan Kettering Cancer Center

🚨 Excited to share our latest paper in Cell identifying how under-replicated chromosomes in micronuclei become shattered by the Fanconi anemia pathway during mitosis. This work was led by UTSW Graduate School of Biomedical Sciences student Justin Engel. 🧵 (1/13): cell.com/cell/fulltext/…

Together with Charles Swanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…nature.com/articles/s4158…... 🧵below

Very pleased to share our new online pre-print! We explore the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in human glioblastoma. biorxiv.org/content/10.110…. A 🧵

Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00

⚪️🧬Un macroestudio liderado por Oriol Pich (#IRBalumni, ahora en The Francis Crick Institute) y Chris Bailey, revela diminutos círculos de ADN en las células de pacientes con algunos tipos de #cáncer, como el de mama #HER2+ —uno de los más agresivos— y el #glioblastoma en el cerebro. 🗣️

Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in nature

Tweetorial below on the paper Coordinated inheritance of extrachromosomal DNAs in cancer cells, published yesterday in nature. ✍️ Written by King L Hung, who's one of the first authors. Read 👇

A tweetorial for our work: we revealed an actionable therapeutic vulnerability of ecDNA by targeting hyperreliance on the replication stress (RS) regulation machinery in ecDNA-bearing tumour cells, which arises from pervasive transcription on ecDNA. 1/14 nature.com/articles/s4158…

The AUTO4/librat1 trial has published results from initial 10 patients with PTCL treated with anti-TRBC1 CAR-T cells. Headline results: 40% CR including 2 in remission beyond 2 years, 3/4 CRs at highest dose. 1/ nature.com/articles/s4159…

🚨So proud to present the first study from our Computational Cancer Genomics (CCG) Research Group group together with Charles Swanton Nnennaya Kanu and led by Olivia Lucas with key collaboration Sophie Ward and fundamental support Rija Zaidi Abi Bunkum & many others Out in Nature Genetics 👇 doi.org/10.1038/s41588… 🧵👇

1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…

We managed to get one last paper rdcu.be/d5gAe over the line before the new year🥂! We are pleased to share the first Nature Cell Biology paper from our lab functionally validating the role of a frequently occurring lung cancer driver, FAT1 in cancer evolution. 🧵1/13

🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells. Out today in Nature Genetics doi.org/10.1038/s41588… 🧵👇

4 DAYS until the abstract deadline for our ecDNA conference ⏰ Learn more: bit.ly/4bCgcAW

🔥New #review out! We explore how experimental models and high-throughput sequencing (or, all the ✨#omics✨) complement each other in #metastasis research. Bridging these approaches can unlock deeper insights into #cancer progression and #treatment

Now online in Cancer Discovery: Spatial-Temporal Diversity of #ecDNA Shapes Urothelial Carcinoma Evolution & Tumor-Immune Microenvironment - by Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han, and colleagues doi.org/10.1158/2159-8…

The potency of abnormal genetic fusion in chronic myeloid leukaemia in our latest study nature 👉🏽 nature.com/articles/s4158… This cancer is an oddity - one of the few single genetic “hit” cancers, a short trajectory (few years) from start to diagnosis, and explosive growth.

A big thank you for highlighting our work 🙏🏽 🙏🏽

A beautiful study led by my brilliant colleagues Oriol Pich Elsa Bernard that opens up the impact of tumour infiltrating clonal haematopoiesis