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Target DNA-induced filament formation and nuclease activation of SPARDA complex Learn more about short Argonaute-based bacterial defense system in our webpage. nature.com/articles/s4142…

Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. #GPCR #Arrestin Shanghai Jiao Tong University nature.com/articles/s4142…

Grow AI virtual cells: three data pillars and closed-loop learning #AI Westlake University nature.com/articles/s4142…

A phytoalexin dismantles bacterial type III injectisome. A research highlight of a recent article published in Science nature.com/articles/s4142… University of South Carolina Peking University Science Magazine

The April issue of Cell Research is now live! Discover 6 highlights, 4 articles, and 2 letters, including Rui Qin et al.’s work on pages 265–283 nature.com/cr/volumes/35/…

Identification of a GPCR as a tip link-independent equilibrioceptor A research highlight of a recent paper published in Cell Research. #GPCR FuDan University nature.com/articles/s4142…

Mechano-pharmacology of T cell receptor specificity A research highlight of an article recently published in Cell Research. University of Oxford nature.com/articles/s4142…

The night shift: norepinephrine drives glymphatics A research highlight of an article recently published in Cell. #sleep #neuroscience WashU Medicine University of Rochester Jonathan Kipnis 💔🎗️ Maiken Nedergaard Cell Press nature.com/articles/s4142…

Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells The study offers new targeted therapy for PDAC. nature.com/articles/s4142…

WIMI is excited to share Prof. Fang Xiaofeng at Tsinghua University “A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis” 📚published in Cell Research nature.com/articles/s4142…

A review article authored by Petr Broz is online: Pyroptosis: molecular mechanisms and roles in disease nature.com/articles/s4142…

Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H nature.com/articles/s4142… Structural Biology at St. Jude Children's Hospital St. Jude Research

Structural basis of stepwise proton sensing-mediated GPCR activation nature.com/articles/s4142… ShanghaiTech University

Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex Human Argonaute2-siRNA complexes undergo precise and tightly regulated structural adaptations to function as efficient, multiple-turnover enzymes in gene silencing. nature.com/articles/s4142… Westlake University

Pyrimidine synthase CAD deamidates and inactivates p53. nature.com/articles/s4142… FuDan University

Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1. Discovery of a novel small molecule, BIEGi-1, targeting both Rheb-GEF and kinase activities of EGFR, for therapies against cancers with EGFR mutations. nature.com/articles/s4142…

Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus. nature.com/articles/s4142… Zhejiang University

A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis. Phase separation and condensation of FUST1 primes stress granule assembly for thermo-adaptation in plants. nature.com/articles/s4142… Tsinghua University

DNA remnants in red blood cells enable early detection of cancer. nature.com/articles/s4142… Westlake University