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This top paper from 2023 highlights the atomic structure of mitochondrial uncoupling protein—UCP1—which allows brown adipose tissue to burn calories as heat. Understanding its regulatory mechanisms offers the potential for targeted metabolic therapies: scim.ag/5yR

In very good tradition of celebrating beautiful data, the image has been stuck on my door for some time now!

Mark's tour-de-force work shows that the ABC transporter BacA from Mycobacterium mediates unprecedented bi-directional transport of cobalamin. Great team effort with Solène and Chancie T - chanciet.bsky.social (Chancie) nature.com/articles/s4146…

April issue is out! We focus on membrane proteins. 📸cover Valeria Kalienkova 🇺🇦🌻 Cristina Paulino @Lynagh_Lab et al. report structures of an FMRFamide-gated sodium channel in several functional states, disentangling how different invertebrate receptors recognize similar neuropeptides.

Cobalamin decyanation by the membrane transporter BtuM | Structure sciencedirect.com/science/articl…

Can AI help us to formulate new hypotheses on the known protein universe?🔎 We definitely think so! Here we describe a new "transceptor" case, linking membrane proteins involved in transport (S-components) to signal sensing (5TMR-sensor histidine kinases). nature.com/articles/s4200…

Bacterial S-components have crossed the border between transporters and receptors doi.org/10.1038/s42003… Congratulations to Michele on finding this unexpected "transceptor" link

It took some time, but Anna’s Anna Borowska beautiful work on the exchange mechanism of ASCT2 is now out. Together with twitterless Gabriella and @CPaulino Alisa Garaeva Jan Rheinberger Siewert-Jan Marrink nature.com/articles/s4146…

Could not be more proud to share my first PhD paper with you! Find out what makes an amino acid transporter ASCT2 function as an exchanger: rdcu.be/dPTze

Researchers including Anna Borowska Cristina Paulino Membrane Enzymology untangle the structural basis of the exchange mechanism of Na+ -dependent obligatory amino acid exchanger ASCT2. nature.com/articles/s4146…

Two open fully funded Postdoc positions in my lab in #cryoEM & #cryoET. See description below 👇Please share and spread the word. For all those interested in joining my group and work on exciting and collaborative projects please apply! drive.google.com/file/d/1Qs4roS…

Building on the work of Richard and Chris, here is our latest work showcasing the potential of the 100 keV #Tundra microscope with the Ceta F and Falcon C. We achieved high-resolution structures for a variety of protein complexes🧵.🔬#100keV #CryoEM. Movie by lingboyu

Next level reconstitution: Combining the malate decarboxylation pathway with transporters (GltP, LacY) in liposomes, Miyer and Zaid generated stable proton and electrical potential gradients and accumulation of glutamate and lactose over periods of hours.nature.com/articles/s4146…

If you are interested in a joined effort towards building a synthetic cell (including -of course- membrane transporters), have a look at this post: nature.com/naturecareers/…

We have a new Research Assistant position open! Please apply and join our team if you are interested in Tissue Regeneration! ecsr.fa.us2.oraclecloud.com/hcmUI/Candidat…

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters researchsquare.com/article/rs-582…