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People routinely use Venn diagrams to show genes expressed in different conditions, such as cell types, and argue for cell-type specific expression based on the imperfect overlap. This is wrong and reflects a lack of the very basics of statistics. You can have imperfect overlap

Grateful to have the opportunity to contribute to the unexpected discovery! The first #RBP I know (a noncanonical one!) that has co-evolved to accommodate #Alu expansion in primates. It surprisingly binds to a single Alu inserted into genes in the antisense orientation.

Precise RNA targeting with CRISPR–Cas13d go.nature.com/4gEn95x

Found this card outside my office this morning - "#RNA has #U in it". Someone is reminding me to hold on? I guess I should continue my NIH grant reviews, although they stopped giving grants...

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

In this study, Bangru et al. describe a regulatory switch that controls hepatocyte polyploidization and maturation through the activation of an RNA alternative splicing program that promotes cytokinesis failure and binucleation. Learn more here: ➡️ tinyurl.com/gd352129

Given some recent publications regarding #RNA #Splicing prediction using #DeepLearning we decided to assess some of those claims with surprising findings that have to do more with the target function you chose… biociphers.wordpress.com/2025/04/09/tis…

Happy to share our update to LeafCutter, which allows the study of unproductive splicing from short-read RNA-seq. We report findings from analysis of 3 large datasets (GTEx, multi-tissue development in 7 species, Alzheimer brains from AD FunGen consortium). See thread by Carlos.

What a world… science.org/content/articl…

Thank LomvardasLab for the shout out! This is a great collaboration with Zha Lab! I guess #RNA always comes in to play a role when one does not expect them to - in this case Ku turns out to be the first (non-canonical) RBP I know of that co-evolves with Alu expansion!

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank Chaolin Zhang Hachung Chung at Columbia University Lena Steckelberg More to come nature.com/articles/s4158…

A set of non-coding genetic variants -- mutations in RNA genes-- cause neurodevelopmental disorders by disrupting alternative splicing across the genome nature.com/articles/s4158…

Excited to announce a 2 week Cold Spring Harbor Asia (CSHA) summer course on Computational Genomics Aug 9-23, co organized by Jingyi Jessica Li Jingyi Jessica Li (李婧翌), Qiangfeng Cliff Zhang, and myself. Application deadline June 8. CSHL Courses Cold Spring Harbor Asia csh-asia.org/?content/2818. CSHA is

Excited to report that our work to infer neuron type specific splicing-regulatory networks and splicing factor activities is now published in Cell Reports. Led by a recent graduated PhD student Dan. See 🧵⬇️. cell.com/cell-reports/f… Columbia Vagelos College of Physicians & Surgeons Columbia Systems Biology #rna

Look forward to reading it!

We are excited to bring to you the Virtual Cell Challenge, a new benchmark initiative from the Arc Institute to evaluate predictive models of cellular response to perturbation.

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In Cell, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…