Excited to announce that our group's work on chemical biology technology at Weill Cornell Medicine at is now funded via a NIGMS R35 MIRA grant!

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

Our latest work led by Daniel Ball shows that oxidized, but not reduced, TRX1 binds to and represses the NLRP1 inflammasome, revealing that the innate immune system senses reductive stress. science.org/doi/10.1126/sc…

Can anyone guess what’s going on here?

The Mickolajczyk Lab Rutgers - RWJMS Office for Research is hiring! We are looking for both a postdoc and a research specialist to join us in using single-molecule techniques to study ATPase motor proteins in ribosome biogenesis. Please RT and share! jobs.rutgers.edu/postings/185185 jobs.rutgers.edu/postings/185189

Had a little too much fun playing with blue lights this week… #photonfriday

Doubleheader in JACS! An awesome collaboration with Merck on leveraging μMap toward the mapping of protein binding sites. Congrats Sean Huth Sean Huth, James, @CiaranSeath, Jacob Geri, Aaron, and the whole team at Merck! pubs.acs.org/doi/abs/10.102…

The Geri Lab is recruiting postdoctoral scholars to develop photocatalytic proximity labeling and proteomics technologies. Chemical biologists and chemists who want to learn chemical biology are welcome! gerilab.weill.cornell.edu/team The view from our recently expanded NYC lab space:

God have mercy

Very excited to share our new bioRxiv! Big thanks to all the co-authors who contributed to this story on Covalent targeting of splicing in T cells! Kevin A. Scott, Hiro, Nathalie, Charles Warren @teezhangg Xiaoyu Zhang Read more below!

Super excited to see my most recent work (and first paper!) from the Kapoor Lab online J. Am. Chem. Soc.! By taking advantage of electrophilic 'scout fragments', we identify allosteric inhibitors of helicases, enzymes that have been challenging to target. pubs.acs.org/doi/epdf/10.10…

Changing my thesis research

OBC was delighted to sponsor such a wonderful event and a big congratulations to Charles Warren Charles Warren from the Jacob Geri lab at Weill Cornell Medicine for winning the OBC poster prize!🎉

Gotta love the restricted access irony

Excited to see the final version of our manuscript out in CellChemicalBiology! In this study, we investigate the mechanism of action of an immunosuppressive small-molecule electrophile, which targets a core splicing factor SF3B1! Rockefeller University authors.elsevier.com/a/1k9mh8jWWJxM…

Happy to share this work from my rotation in Katya Vinogradova ‘s lab! This was my first experience preparing proteomic samples and a deep dive into the power of cysteine ABPP to discover new biology. Thank you to everyone who helped bring this together!

Online now! Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova Katya Vinogradova and colleagues at Rockefeller University TPCB Weill Cornell Medicine Memorial Sloan Kettering Cancer Center Scripps Research dlvr.it/TGR63y #chembiol

Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova Katya Vinogradova and colleagues at Rockefeller University TPCB Weill Cornell Medicine Memorial Sloan Kettering Cancer Center Scripps Research dlvr.it/THQfxm

I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces. biorxiv.org/content/10.110…