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The AEpiA ECR Representatives are delighted to announce the winner of the 2024 Emma Whitelaw ECR Publication Award is 🥁🥁🥁.... ✨ Charles Bell Charlie Bell ✨

The genetic architecture of protein stability by Andre Faure @ajfaure.bsky.social Aina Martí cristina hidalgo-carcedo @ToniBeltran13 Joern Schmiedel nature.com/articles/s4158… Centre for Genomic Regulation (CRG) Wellcome Sanger Institute ALLOX

You mean mass redundancies, the evisceration of entire disciplines, rampant managerialism, and the fanatic embrace of a profit-driven model of scholarship haven't fostered a climate of open inquiry and big ideas? Who could've known?! 🤷‍♂️ theguardian.com/australia-news…

I’m excited to share the programme of my new series of lectures ⁦Collège de France⁩ in Nov-Dec. I will devote next 2yrs to information flow. As usual, I speak en Français, but all slides (pdf) in English, self-explanatory, video on Youtube. Stay tuned or visit if in Paris. It’s free

Happy to share that the paper on enhancer interactions led by Jessica Zhou and I from my time in the Graham McVicker lab is now published in Cell Genomics! cell.com/cell-genomics/… A thread on some of the new analyses below: (1/n)

Great to see Vasan‘s stunning work on Pol II termination out. Pulling on nascent RNA leads to hypertranslocation and destabilization of the elongation complex.

Nature research paper: Machine-guided design of cell-type-targeting cis-regulatory elements go.nature.com/3A0nksF

One in all in charliebell.bsky.social

A lot of folks in artificial intelligence (AI) & robotics seem to keep forgetting that what people do on a daily basis, like identifying, picking up & holding a cup of water is a very complicated process from a computational modeling perspective. Moravec's Paradox:

Site-saturation mutagenesis of 500 human protein domains: nature.com/articles/s4158…

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…

Delighted to share our new approach to enhance CAR T cell function in solid tumours published today nature. In this work we identify a new strategy to generate armoured CAR T cells. nature.com/articles/s4158…