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Long overdue, but our first grad student Megan McCurry just defended her thesis in May!🤩 She also just gave an AMAZING talk at #bbm2023 Boston Bacterial Meeting (BBM) on her thesis work. 🎉 What an exciting couple of months!

Summertime view of the Harvard Medical School Quad ☀️ 🌺

The very first preprint from our lab!! We repurposed a rapidly internalizing receptor TfR1 for membrane protein degradation. We show it works on single-pass, multi-pass, native and synthetic receptors. The overexpression of TfR1 on cancer cells offers potential tumor selectivity.

Blue skies over Harvard Medical School ☀️

Congratulations to Harvard Med BCMP faculty Hao Wu! Harvard Medical School

The way Harvard chemist Emily Balskus sees it, the vaginal microbiome is an underappreciated, understudied part of the body where critically important chemistry takes place hrvd.me/VaginalBacteri…

Congratulations to Dana-Farber's Rosalind Segal, Benjamin Ebert, Cigall Kadoch, Eric Fischer, Kimberly Stegmaier and Scott Armstrong on being shortlisted for the next Cancer Grand Challenges Challenges awards! bit.ly/47A1Oqz (Photo by Ken Richardson Photo) #CancerGrandChallenges

Welcome back everyone!

Please share! The Devlin lab is looking for postdoc fellows. Candidates with experience in either 1) tissue culture & cell-based assay development or 2) analytical chemistry, biochem, or organic chem. are encouraged to visit our lab website & email Prof. Devlin directly. (1/2)

Our Journal of Biological Chemistry review on the regulation of 1C metabolism is now out. Check it out (or at least the figures :) ) Kanarek.Lab doi.org/10.1016/j.jbc.…

Our article elucidating the structural role of Lig4 in DNA end synapsis during NHEJ is now out at Nat Comms link.springer.com/10.1038/s41467…

Congratulations to Whitney Lieberman in our lab who had just been officially awarded an NIH F31 fellowship to support her exciting graduate studies! We are thrilled!! Kadoch Lab Harvard Chemical Biology PhD Program

The first prime editing clinical trial has been cleared by U.S. FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to Prime Medicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.

Big news!! The culmination of my PhD work is out now in Cell: “Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.” Just some gut bacteria doing cool chemistry that may impact pregnancy phenotypes, check it out! authors.elsevier.com/a/1j8j7L7PXqQmM

How do intrinsically disordered regions (IDRs) regulate protein function? Today in Molecular Cell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6) sciencedirect.com/science/articl…

Congrats to Drew who defended his thesis last week and hosted an impressive Thesis Showcase that celebrated the journey to his PhD - triumphs, travesties, spectacles and all. Congrats, Drew! Drew Dates #PhD

Check out our new paper published Cell Host & Microbe! Lithocholic acid (LCA) is a metabolic toxin decreased by bariatric surgery. Taurodeoxycholic acid, which is increased by surgery, inhibits LCA production by microbes and has metabolic benefits. authors.elsevier.com/a/1jTSj6t8JEqo……

Excited to see our collaborative work with OserLab Dana-Farber Dana-Farber News on #SCLC #lungcancer out in Cancer Cell, identifying chemically targetable #BAFcomplex chromatin regulatory dependencies and providing foundation for new clinical studies for this aggressive cancer.

Excited to join the HHMI community - made possible by talented lab members, current and former, and amazing colleagues at @HarvardCellBio and beyond!

A recount and update on our efforts to bring base editing to progeria patients as part of a team including Francis Collins, Sammy Basso, Mike Erdos, Leslie Gordon, @Progeria Luke Koblan, Meirui An, Xin "Daniel" Gao, and others, beautifully told by Gina Kolata in the The New York Times: