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Results in this new preprint provide a major leg up for efforts to drug brachyury: biorxiv.org/content/10.110… Some highlights: 1. Crystal structure of WT and G177D brachyury in complex with DNA 2. Crystallographic fragment screening of brachyury 3. Identification of numerous

Tweetorial ascopubs.org/doi/pdf/10.120… 1/ #CaboNivo & #CaboNivoIpi have shown promising efficacy and safety in patients with metastatic urothelial carcinoma #mUC, metastatic renal cell carcinoma #mRCC & rare #GU tumors in a dose-escalation phase I study ascopubs.org/doi/full/10.12…

Aristotle was the first to notice honeybees dancing. In 1927 Karl von Frisch decoded the waggle. How it works was "explained" by MV Srinivasan AM FRS in the 1990s. Except Laura Luebbert, PhD found his papers are junk. A 🧵 about her discovery & our report: arxiv.org/abs/2405.12998 1/

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Aegean / Ionian

Companies cash in by selling honors like “Best Doctor” or “Top Doctor” to physicians. Experts call it a “scam.” Giving one to a ProPublica reporter who wasn't a doctor only highlighted the absurdity. propublica.org/article/top-do…

A real-world validation of the value of #wearables in assessing treatment effect in #Oncology by Vivek Venkataramani at Universitätsklinikum Würzburg nature.com/articles/s4169…

🔥 Excited to present iterative MedRAG (i-MedRAG) that pushes the performance of GPT-3.5 to ~70.0% on MedQA. Great work led by Guangzhi Xiong!

An analysis of demographics of participants in clinical trials at the NCI Clinical Center from 2005-2020 compared with the U.S. population and other trial mechanisms finds disparities in clinical trials. Read now: oxford.ly/3LPWIwP Fatima Karzai, M.D.

Ponsegromab for the Treatment of Cancer Cachexia NEJM doi.org/10.1056/NEJMoa… 👉Ponsegromab = humanized monoclonal antibody inhibiting GDF-15 👉Weight gain: 1.22 kg (100mg), 1.92 (200 mg), 2.81 (400 mg) 👏very promising effects on tumor cachexia ESMO - Eur. Oncology

Excited to attend the #AACRdisp24 Conference on Cancer Health Disparities with a travel award from @NCIResearchCtr @NCICCR_MOS!

Checkpoint inhibitors are increasingly common and often highly effective cancer therapies But they can cause hepatitis This systematic review shows: 1 in 6 are steroid refractory 1 in 5 recurs with rechallenge Wei Zhang MD PHD Hepatology Communications journals.lww.com/hepcomm/fullte…

Some kids with Cushing hypercortisolism are not obese. Curious if that's biological/behavioral/combination. academic.oup.com/ejendo/advance…

DNA copy number variation is strongly buffered at the protein level. The buffering is much stronger than at the RNA level.

A great presentation of important work to increase equitable representation in clinical trials by whenwetrial.org Touch, The Black Breast Cancer Alliance ™️ at #AACRdisp24.

Our own Dr Cecilia Monge B, MD NCI CCR Med Onc Service showcasing her work on CRC genomic research inclusion #AACRdisp24

Thrilled to report Patho-DBiT, just published in Cell 😊. It allows us to directly “see” all kinds of RNA species on the same clinical FFPE tissue slide, including mRNA, miRNA, snRNA, snoRNA, tRNA, etc, and splicing isoforms, genetic alterations (SNV, CNV, etc). Really a fun,

🔥 Excited to share our TrialGPT work published in Nature Communications today. 🧪 Patient recruitment is challenging for clinical trials. 🤖 We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models. nature.com/articles/s4146…

Had a terrific time collaborating with Wei Zheng, Sisi Sarkizova (Moderna) and Michele Ceccarelli (Sylvester Comprehensive Cancer Center) for a review on mRNA-based neoantigen-directed cancer immunotherapy, now available from Journal for ImmunoTherapy of Cancer jitc.bmj.com/content/13/1/e…

I am deeply grateful to my co-authors from Center for Cancer Research, National Cancer Institute, NIH (Bethesda 🇺🇸) @gulleyj1 Andrea Apolo, M.D. Fatima Karzai, M.D. Elias Chandran, MBBS @elisabetta Elisabetta Xue