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Spatial multi-omics reveals cell-type-specific nuclear compartments nature Cai Lab Yodai Takei nature.com/articles/s4158…

When RNA damage induces DNA breaks dlvr.it/TK4l7c

Excited to share our new paper out in nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…

Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 Fusion Conferences Karim Mekhail Irene Chiolo. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: fusion-conferences.com/conference/188

Online Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 dlvr.it/TLBMbH

Exciting new story from Irene Chiolo out in Molecular Cell showing Nup98 droplets driving faithful DSB repair! Big shout out to leading 💫 Chiara Merigliano 🍾🍾

Hidden DNA repair system that could transform cancer treatment and slow #aging. Scientists find 'condensates' formed by the protein Nup98 help cells avoid catastrophic errors when repairing breaks in tightly packed DNA. By Anik Mitra, Irene Chiolo,et al. doi.org/10.1016/j.molc…

Big thanks to Aga Gambus Chowdhury Lab for their fantastic talks and to our amazing community for the rich discussions! Next up: September 9th with Ruben van Boxtel and Sophie Polo Lab. Enjoy summer & stay in the loop 👉: docs.google.com/forms/d/e/1FAI…

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… Eric Betzig Legant lab

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

Absolutely insane amount of data in this resource from Chris Mason The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs biorxiv.org/content/10.110… Spatial data on 15million cells from 100 donors across multiple ages, mainly GI

Online Now: A unified pan-cancer proteome atlas dlvr.it/TLPtvc

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Want to better understand nuclear and genome organisation in various organisms, tissues, and cell states? Join Karim Mekhail , altmeyerlab & Irene Chiolo at the upcoming 2nd Spatial Genome Organisation Conference this October! Talk Submission has been extended until 14th July,