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When you offer to finish an experiment for your grad student and say “leave me instructions like I’m in kindergarten”…

Things I wish more people knew about doing science in the US (thread):

Spending 5 minutes on this website.

Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)

Writing can move ideas forward, even if everything else feels stuck. Tips for efficient collaborative writing and reference management in Google Docs, via Emma J Chory 🔽

Read: OpenAI raised $40B in one round—i.e., the entire NIH budget.

Counterpoint: Physics-derived modeling has dramatically improved clinical trial success rates and efficiency. QSP is one of the most sought after skill sets and highest paying job tracks in pharma right now.

Last week, I had the pleasure of visiting the Duke University Center for Biomolecular and Tissue Engineering to discuss our latest work using AI to accelerate antibiotic discovery. Thank you Pranam Chatterjee, Emma J Chory, Sophia Vincoff, and more!

How are folks handling NIH’s no foreign subawards policy? Anyone working with consortia (e.g. Human Human Protein Atlas, Sweden), this is a big issue—some orgs are the only source for rare reagents/proteins, sold at cost. Curious what implications this has + how ppl plan to navigate.

For anyone still not taking this seriously, this is what defcon 1 looks like re: the end of America as a scientific superpower. Heartbroken for our Harvard colleagues and for the world to lose these discoveries.

Harvard notified me today that this K99 grant is terminated.

Just checkin’ the till here, The Boston Globe, but I think you missed a few thousand. Per my last count, Harvard University has 13 affiliated hospitals, 2000+ PhD students and over 5000 postdocs.

The NIH notified me yesterday that there is currently no policy that supports applying for a R00 that is associated with a terminated K99. So now, both the postdoc K99 (Harvard, $250k) and the R00 (non-Harvard institution TBD, $750) are BOTH effectively terminated.

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi FURUHATA, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…

A phenomenal interview with the scientist we owe multiple fields of science to. Thank you David for such phenomenal work and for communicating the importance of public funding with such clarity and purpose. Everyone should take 10 minutes to watch this.

Amazing talk by Emma J Chory about directed evolution, robotics and automation. Also very interesting links for education #SEED2025

:snaps: :snaps: :snaps: Just loved this, Erika Alden DeBenedictis! We’re obsessed with better ways to track & share science. This ELN+LIMS built in Notion + Airtable is usable, readable, and full of real stats & insights. and it's pretty!