Karol Buda, Charlotte Miton with colleagues in the Tokuriki lab perform statistical analyses to demonstrate that epistasis is highly pervasive in adaptive evolutionary trajectories of enzymes. #epistasis, #proteinevolution nature.com/articles/s4146…

Excited to share our new preprint! We have done a comprehensive bioinformatic analysis of β-lactamases (all major five classes together). The work pretty much repaints our understanding of how β-lactamases are distributed in the environments. biorxiv.org/content/10.110…

🧪B-lactamases can inhibit biofilm formation. On the side, the evolution of a #biofilm lifestyle can counteract this pleiotropy by selecting for genetic variation within b-lactamases, shaping their evolutionary fate. Work led by Øyvind Myrvoll Lorentzen Evolution never stops to amaze me!✨

Still time to apply and register for NordBio II - Nordic Midsummer Symposium on Biocatalysis, 13-14 June 24! sites.google.com/view/nordbio-2…

Are you ready to push the boundaries of #LifeSciences? #HFSPFellowship Program is now accepting Letters of Intent. Learn about the LTF and CDF fellowships for PhD researchers at bit.ly/3ZMPQp0🔍Dive into a new area of study and work in a new country! #ResearchOpportunity

🚨paper alert🚨 #Epistasis makes combining mutations unpredictable.🤷 This complicates #enzymedesign and predicting the effect of mutations.⁉️ Through in-depth evolutionary analysis, we recently uncovered an underappreciated mechanism for epistasis.🧬♻️🔍 nature.com/articles/s4192…

Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint Hollfelder Lab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️

Antimicrobial resistance may evolve more rapidly than previously thought | In a study in Nature Catalysis, a team led by Adrian Bunzel 🇪🇺🇨🇭🇩🇪🏳️‍🌈 Panke Lab and Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 UiT Norges arktiske universitet revealed a novel mechanism for how resistances can emerge alarmingly fast >u.ethz.ch/fNMrR

Our exciting collaboration with the great Tokuriki lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. nature.com/articles/s4146…

🌍 Team up with Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 and me to tackle antimicrobial resistance! Apply with us for an #HFSP Postdoctoral Fellowship to combat #AMR with #deeplearning, #proteindesign, and #directedevolution.🧬🔬 hfsp.org/funding/hfsp-f…🌟 #ScienceFunding #Postdoc D-BSSE, ETH Zurich UiT Norges arktiske universitet

How will the inclusion a microbial species change the function of a community? How will the acquisition of a specific mutation change the phenotype of an organism? Both questions can be addressed using a same quantitative framework. Find out more: doi.org/10.1016/j.cell…

For the Norwegian crowd: Oppdag hvordan små genetiske endringer i bakterielle enzymer kan føre til stor antibiotikaresistens. Lær om det fascinerende fenomenet epistase og dets betydning for utvikling av fremtidige medisiner. 🦠🔬 forskersonen.no/antibiotikares…

🚨β-lactamase expression induces collateral sensitivity in Escherichia coli🚨 Our new paper, spearheaded by the great CHerencias and Laura Álvaro Llorente, has been published in Nature Communications!!! Great to see this collab with the fantastic @AlvSanMillan out!! nature.com/articles/s4146…

🌟 Feeling incredibly grateful today as I've been awarded the #EarlyCareerScientistAward by UiT Norges arktiske universitet. Huge thanks to everyone who's guided, supported, and inspired me along this path. Here's to more research, and collaboration. #EarlyCareerAward #Science #UiT

🔬 Thrilled to have presented our research at #FEBS2024! 🧬Mutations can shift the rate-limiting steps in enzyme reactions during evolution, creating strong synergistic effects. 🙏Thanks to everyone for participating and all the positive engagement! doi.org/10.1038/s41929…

Awesome having Karol Buda from the Tokuriki lab visiting UiT Norges arktiske universitet. 🍺 for the next round of collaboration!

This account beat me to it… a very talented HFSP postdoc with me (John Chen no twitter) has developed a hierarchical clustering method that overcomes many of the issues with traditional seq similarity networks.