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Alphafold2 refinement improves designability of large de novo proteins • Introducing af2cycler, a pipeline that enhances the designability of large de novo protein backbones, combining AlphaFold2’s refinement and ProteinMPNN for sequence optimization. • Af2cycler achieves

This is awesome! Generate a binder, insert it onto a CAR, kill cancer cells reliably! Stunning results!

For round three we need a Foldit puzzle Would be hilarious if some random person outperforms all the ML methods 😅

I somebody up to date about the legal aspect of redesigning existing antibodies etc? Just wondering how dis-similar a sequence needs to be, to be able to be used again? Nevertheless, the results are 🔥🚀

@milot_mirdita @thesteinegger thanks for all of your hard work.

🧵1/8 In ~2020, diffusion models gained popularity with famous AIs like DALL-E. But diffusion models work well for protein design? Yes! Chroma is a diffusion model that designs proteins from scratch, with its details described in >100 pages (compared to the 62p of AlphaFold2)

Fard über Elon Musk, Alice Weidel und die AFD

Estonia is now 0% bureaucrazy! We’re proud to announce that every government service in Estonia is now fully digital. Whether signing documents, starting a business, paying taxes, or sorting out your healthcare, it’s all handled with a click. #digitalnation #eestonia #bureaucrazy

I became aware of the true Munich-Augsburg rivalry today🚀

New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design. Preprint: biorxiv.org/content/10.110… Code: coming soon Animation credit: x.com/ichaydon (1/n)

Thats how one does ads 😅

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