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Great talk by Chris Lo 💊🧬🧠 on the final day of #WCPG2024 mood disorder session discussing SRRI switching, it’s current utility and future prospects. ISPG SGDP Centre KCL

🚨New preprint alert 🚨 from AMBER group Dr Cathryn Lewis Shoutout to Michelle Kamp ‘s work on ‘self-reported #antidepressant response’ data using UK Biobank mental health questionnaire data! Characteristics resembles known evidence of SSRI response in clinical trials.

interesting work by Lachlan Gilchrist on MR between metabolites and psychiatric disorders!

Chris Lo 💊🧬🧠 UK Biobank Generation Scotland Matthew Iveson Evangelos Vassos Naomi Wray Andrew McIntosh Alexandra Gillett Michelle Kamp Chiara Fabbri Heather Whalley SGDP Centre KCL medRxiv Switching patterns 👉Median time to switch: 28 days 👉 Switching to SSRI (50%), TCA (33%) or other drugs 👉More recent prescriptions had ⬆️switching %, ⬇️ shorter time to switch 📷4/7 - our favourite figure

Here’s my turn for a preprint :) Medrxiv link: medrxiv.org/content/10.110…

Our new paper is a pharmaco-epi study on associations of montelukast with neuropsychiatric conditions in children and adolescents

The 2023 ACC/AHA #AFib guideline recognizes AFib as a disease continuum that starts with patients at-risk but without diagnosed AFib (Stage 1) and progresses to those in a permanent state of AFib (Stage 4). Learn more from the AFib Guideline Hub: bit.ly/3Nge8Uo

Merry Christmas everyone 🎅🏻 Thank you for the messages today ❤️ WOW it’s been an emotional one 🥹 Tune in to BBC Breakfast tomorrow morning 8.15am to watch us live and hear all about our day with the reds 😬🔴⚽️ YNWA!!

Excited to be completing my first book “How psychedelics work” early in the new year. 12/13 chapters written. As I say in the intro, it could just as easily have been titled differently, like these:

🚨So delighted to see this work looking at the genetic overlap between depression symptoms and Alzheimer’s disease now published in Nature Mental Health Springer Nature🚨 Read the paper here: 👉 nature.com/articles/s4422…

Three quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research. Read more➡️kcl.ac.uk/news/three-qua… #SSRI Wellcome The University of Edinburgh NIHR Maudsley Biomedical Research Centre (BRC)

Next up at our Data Science Meeting, Chris Lo 💊🧬🧠 from King's College London introduces T-Rx: an R package that simplifies the processing of prescription records into exposure periods and treatment-related #phenotypes. This toolbox makes it easy to work reproducibly across databases,

Who benefits from antidepressants? New research from IoPPN (Dr Cathryn Lewis, Chris Lo 💊🧬🧠) shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others kcl.ac.uk/news/who-benef…

Polygenic risk score (PRS) tools are getting better and better! Yue Li & team at McGill report a major update to their PRS software, VIPRS (variational inference of polygenic risk scores) — now lightning fast & ultra-efficient. VIPRS reads ultra-compressed LD matrices (MBs not

New study Nature Genetics identifies first genetic risk factor for long COVID. They compared DNA from 16,000 patients vs 1.9 million controls across 24 countries. Here are my key takeaways 👇

Millions are spent on parenting interventions. Are they effective at preventing mental health problems? Turns out we can’t be sure…only 2/32 of the reviews in our metareview were of high quality, highlighting the need for robust evidence synthesis. mentalhealth.bmj.com/content/28/1/e…