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With our colleagues from Italy we describe how a genetic change in a gene coding for a componant of mitoribosome leads to #mitochondrialdisease | very 1st paper of our PhD student Chris Mutti - Congrats! Erika Fdez-Vizarra MRC MBU Bambino Gesù Istituto Neurologico Carlo Besta sciencedirect.com/science/articl…

Excited to share this new paper from the lab: a novel factor involved in building up the mitochondrial ribosome | Spearheaded by AD /Aaron R D’Souza+Chris Mutti Pedro Rebelo-Guiomar et al. | Thanks for perseverance! Nucleic Acids Res academic.oup.com/nar/advance-ar…

Congrats to Eva Schöller,Marchand Virginie Chris Mutti C.Powell & many more! Molecular Cell The role of METTL8/m3C in mito. translation sciencedirect.com/science/articl… A great collaboration with G.Meister lab Universität Regensburg Brenda Helm Markus Hafner et al. THX for getting us involved!

Today Pedro Silva-Pinheiro etal. report on the in vivo use of mito DNA base editing #DdCBE to install a novel #mtDNA mutation in the heart of adult and neonatal mice. This PoC that could lead to future therapies for #MitoDisease Nature Communications MRC MBU Chris Mutti nature.com/articles/s4146…

Errors in the DNA of our #mitochondria – the batteries that power our cells – cause devastating diseases. Researchers MRC MBU have shown in mice that it may be possible to correct these errors using gene-editing: bit.ly/3GBQLhU Medical Research Council The Lily Foundation The Champ Foundation

Happy to contribute to this article in The Biochemist, please check it out!

Treatment for mitochondrial diseases has the potential to be aided by recent developments in mitochondrial genome engineering. doi.org/10.1042/bio_20…

Pleasure to contribute to this pioneering study - congrats to Mito@GU Benedict Tan

Online Now: The human mitochondrial genome contains a second light strand promoter dlvr.it/SXVS2Y

The MRC MBU Mito@GU & Division of Molecular Metabolism, KI spin-out company pretzeltx.com launched officially today with $72.5M Series A financing🥨🚀 Looking forward to Pretzel's future work on treatments for diseases in which mitochondrial dysfunction plays a role pretzeltx.com/pretzel-therap…

Read about recent advances and developments in genetic engineering of mitochondrial DNA and what this means for future treatment of diseases ow.ly/ksPp50KY9w3

Today Pedro Silva-Pinheiro etal. present in Nature Biomedical Engineering a library of base editors #MitoKO to ablate all protein-coding genes in mouse mtDNA. #MitoKO will help generating new, clinically meaningful models for mechanistic, drug discovery and pre-clinical studies nature.com/articles/s4155… 1/8

This work was a terrific Minczuk Lab team effort spearheaded by Pedro Silva-Pinheiro and tremendous contributions from Chris Mutti Lindsey Van Haute Chris Powell, Pavel Nash & Keira T Congratulations!!! 🍾🎉🥳 8/8

A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome nature.com/articles/s4155…

Congrats to Chris Mutti on publishing his PhD research on mitoribosome assembly! This builds upon Lindsey Van Haute's work on the methyltransferase METTL15, revealing that its catalytic activity is not essential for mtSSU biogenesis. tandfonline.com/doi/full/10.10… MRC MBU Postdocs MRC MBU