Single adjuvant therapeutic plasma exchange within 24h after septic shock led to fast hemodynamic improvement in pilot bicentric RCT: ⬇️NE dose, -48% ⬆️MAP ⬆️ratio MAP/NE ➡️relevant changes in coagulopathy/permeability ➡️no adverse events during procedures bit.ly/35XWyyM

Interested in #ARDS #biology? You should read this paper by Peukert et al in ATS Blue Journal. Excellent translational study describing Caspase 1 dependent lung injury in direct causes of ARDS. atsjournals.org/doi/abs/10.116…

Of course it also contains a discussion about diet-induced fasting responses through #ketogenic diet 😜

Antibiotics as immunomodulators: a potential pharmacologic approach for #ARDS treatment: err.ersjournals.com/content/30/162…

Is there a role for therapeutic plasma exchange in #septicshock?🦠 🔍In this research study, therapeutic plasma exchange removed injurious endothelial glycocalyx degradation products and partially attenuated Heparanase-2 defciency. 👉 icm-experimental.springeropen.com/articles/10.11… Sascha David

Bleeding & thrombotic events on #ECMO, consider impact of: 🩸choice of/intensity of anticoagulation + monitoring 🩸pt-specific characteristics Identifying & stratifying pts at risk will facilitate tailored approach 📎rdcu.be/cGZ0x In reply to 📎rdcu.be/cDuGf

There are many ways to parse #ARDS into subgroups 🫁 What if biological patterns could inform future ARDS redefinitions ❓🤔 Read more 📢 rdcu.be/cIK9n #ICM #experimental #ICU #Biomarker #Pathophysiology

Thrilled to announce that DFG public | @[email protected] will fund our multicenter study #EXCHANGE2 on therapeutic plasma exchange in septic shock🎉 👇🏻 bonhanza.com/post/exchange-…

New energy for flagging immune cells: In Covid-19 infected individuals, immune cells do not receive sufficient suitable energy carriers, a study by Wilhelm Lab #UniBonn ImmunoSensation Uniklinik Bonn reveals. Read more in nature (doi.org/10.1038/s41586…) & uni-bonn.de/en/news/172-20…

Our latest study highlighting a link between infection-induced ketogenesis and T cell function nature Huge team effort Fotis Karagiannis Konrad Peukert Laura Surace christian.bode Kasia Placek and many more nature.com/articles/s4158…

Therapeutic plasma exchange in #ICU 🟨 indications for urgent TPE 🟨 mechanisms, kinetics and therapeutic goals 🟨 diagnostic workup & monitoring 🟨 technical aspects 🟨 clinical response & complications 🟨 unanswered questions & research agenda #FOAMcc 📎 rdcu.be/cTAMO

usz.ch/neue-hoffnung-…

Our latest take on the interplay of #helminths and #ILC2 #metabolism, published with Springer Nature in Mucosal Immunology nature.com/articles/s4138…. Big thanks to @PeronaLab and @HenryMcSorley for Organisation and invitation!

Omicron vs. influenza - what will the upcoming season bring? Here some thoughts👇🏻 ja.ma/3Lwqo0R via JAMA part of JAMA Network

Thanks a lot Hongbo Chi Yan Nature Metabolism for highlighting our recent story! #ARDS #Covid #Immunity

Great talk on therapeutic plasma exchange in #sepsis at the #DIVI22. Sascha David presents the rationale for TPE and latest results of the #EXCHANGEstudy.

Great time for the BonHanZA group at the #Divi22: talks from Sascha David and klaus stahl, posters presented by Ben Seeliger , Lennart Wild, Konrad Peukert, Dani, Andrea and Larina and christian.bode receiving the hugo-schottmüller prize for #sepsis research. Congrats! 🥳

Our study protocol for EXCHANGE-2 is out now.... rdcu.be/daNRD

🔥Want to learn more about the phases of capillary leak? ➡️ Increased vascular permeability: aggressive treatment strategies💧 ➡️Recovery phase: stabilizing and optimizing the fuid status with de-resuscitation ☔️ Learn more with this #OpenAccess #Review 👇 icm-experimental.springeropen.com/articles/10.11…

⚙️During ECMO there may be thrombus formation, hemolysis and impaired gas exchange. 🩸Carboxyhemoglobin (COHb) is generated upon red cell lysis. 📰Cohort study to evaluate COHb in the ABG as a novel marker of oxygenator dysfunction! ▶️t.ly/TbcW_