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Genetic first”approach can potentially lead to save money up to 40% when applied with the right workflow ensuring high diagnostic rate!Happy to share our work JASN_News: journals.lww.com/jasn/Abstract/… Paola Romagnani Francesca Becherucci Samuela Landini Valentina Raglianti Gianmarco Lugli Viviana Palazzo

Just published in ASN Kidney360, our perspective reviews the experience of renal genetic clinics and offers sparks on how to integrate genomics in daily clinical practice in nephrology. Luigi Cirillo

Chronic kidney disease in children: an update ow.ly/P51A30sv2Ib CKJ #openaccess #CKD

📢NEW Review: Chronic kidney disease in children: an update 🔓bit.ly/3LA0Hhs 📸Staging of CKD in children and adolescents 📸Causes of CKD in children and young adults and frequency of genetic forms 📸Mechanisms of CKD progression in children

1/ ⏰ Tweetorial time! Before the weekend, let's check the recent review on CKD in children published by CKJ. LetiziaDeChiara is a YNP member! academic.oup.com/ckj/advance-ar… Prepared by Sourabh Sharma and Safak Mirioglu on behalf of the YNP of ERA of the ERA - European Renal Association.

Finally out! New proposed classification of glomerulonephritis focused on etiology, activity and chronicity to optimize patient management. ⁦Hans-Joachim Anders⁩ ⁦⁦Kitching Laboratory⁩ and Nelson Leung academic.oup.com/ndt/advance-ar…

Kidney stones and thiazide diuretics: Revisiting old assumptions in light of the NOSTONE trial ow.ly/MVXV30svy9Q CKJ #openaccess #Urolithiasis #OpenAccess

Our new work on Clostridium Septicum superinfection complicating #HUS just released in Journal of Nephrology: rare among rare. Luigi Cirillo Università di Firenze Fondazione Meyer link.springer.com/article/10.100…

Proud to share our cover and editorial on green nephrology💚!! An amazing and collaborative effort by #ISN_ELP Kidney International Int Society of Nephrology Check it out 👇⬇️ authors.elsevier.com/a/1hHSTJOcprVeE

There are so many things we talk about in medicine that seem like a complete waste of everybody's time. Anyway, I'm putting together a skit on contrast nephropathy should be out soon.

Our editorial on #exome first strategies in medicine is out in NDT Time to change perspective Luigi Cirillo Fondazione Meyer Università di Firenze

Four more important conclusions are: 1. The traditional lesion patterns MCD/FSGS are clinically unuseful to inform about how to treat, 2. More antigens exist, 3. Autoimmune, genetic and adaptive are the main DD, 4. Autoimmune podocytopathies have a good prognosis.

Our new study is out! By STED microscopy on kidney biopsy and ELISA assays we show 1/3 of pediatric and half of adult patients (more in primary FSGS) have autoantibodies against slit antigens different from nephrin. i.e. anti-slit Abs kidney-international.org/action/showPdf…

Anti-slit antibodies define response to therapy and prognosis much better than histopathological lesion patterns even among patients with steroid-resistant nephrotic syndrome kidney-international.org/action/showPdf…

Look how much more important is to know if a patient is genetic or has anti-slit antibodies than if has MCD or FSGS at kidney biopsy. We have finally come to the era of autoimmune, genetic and adaptive podocytopathies. No more MCD or FSGS used as diagnosis!

Proud to share our paper in Kidney International! Excited to see our research on anti-slit antibodies in steroid-resistant nephrotic syndrome published—a significant step toward targeted treatments. Huge thanks to my mentor Paola Romagnani and Maria Lucia Angelotti. kidney-international.org/article/S0085-…

Another important hint from this study: when proteinuria is severe usually genetic or autoimmune podocytopathy. When <4 of P/C ratio these causes still possible but much less likely kidney-international.org/action/showPdf…

Anti-slit diaphragm antibodies on kidney biopsy identify pediatric patients with steroid-resistant nephrotic syndrome responsive to second-line immunosuppressants. doi.org/10.1016/j.kint… Università di Firenze Universitat de Barcelona Universität München #OpenAccess #pediatricnephrology

Our new study reporting anti-slit autoantibodies against podocin and Kirrel1 in a subset of patients with nephrotic syndrome is out in JASN journals.lww.com/jasn/citation/…

Early CKD in young adults with congenital solitary kidney is often missed. Standard tests (eGFR, proteinuria, BP) can look normal. This study shows how renal scintigraphy helps detect silent damage. Better follow-up starts with better tools. Read: doi.org/10.1093/ndt/gf…