🚨 Tweetorial Alert! 🚨 💡 Orthostatic Intolerance (OI) is emerging as a novel framework for understanding dysautonomia-related diseases. A new study in JAHA highlights its key driver: brain underperfusion. 🧠🔍 ahajournals.org/doi/10.1161/JA… 🧵 (1/)

Congratulations to PI Dr. Sergio Caravita, Sub-I Dr. Claudio Baratto, Sub-I Dr. Davide Sala, Enrico Gianfranceschi and team at Istituto Auxologico Italiano on their latest #ALLAYHF randomizations! #atrialshunt #HFpEF #heartfailure #structuralheart #interventionalcardiology

Wow! 😳 P3 #ZENITH RCT stopped early for overwhelming efficacy Sotatercept, an activin signaling inhibitor already proven to slow progression in lower risk PAH, now shown to dramatically ⬇️ death or worsening in advanced PAH HR 0.24 (0.13-0.43) P<0.001 nejm.org/doi/full/10.10…

A key contribution on a major topic "Initial therapy in patients with #PAH and cardiovascular comorbidities" just published in ERS publications Thanks to Athénaïs Boucly Savale Laurent and the Pulmotension network Société de Pneumologie de Langue Française (SPLF) publications.ersnet.org/content/erj/65…

It was a great pleasure to present our research at LBCT session during HFA2025. Sodium is needed for decongesting and effective diuretics. Still more to come. Marat Fudim, MD MHS Rafael de la Espriella EJHF Editor-in-Chief HFAPresident the full paper will be soon published in the best HF Journal @EJHF

Honored to have been invited talking on clinical usefulness of invasive exercise hemodynamics in Vall d'Hebron hospital by Eduard Ródenas Nacho Ferreira Thank you again for the kind invitation, warm hospitality & all the discussions!!!

#heartfailure2025 has been great! A lot of science & connections - 2 LBS sessions & 1 rapid fire abstract on the "Supright protocol" for invasive exercise hemodynamics International 🇺🇸🇮🇹🇵🇱 collaboration with Mark Kittipibul MD Claudia Baratto Jan Biegus piotr gajewski Marat Fudim, MD MHS

So proud of our multinational #Supright team 🇮🇹🇵🇱🇺🇸 sharing our works at #Heartfailure2025. Our #Supright registry is growing with >100 pts w/ combined supine/upright exercise RHC data. Excited to discuss our protocol and expand with other hemodynamic enthusiasts!

Il Prof. Sergio Caravita il 23 maggio all'hospital meeting "Cardiology Scientific Sessions" del Dipartimento di Cardiologia dell'Ospedale Vall d'Hebron di Barcellona, con tenuto un intervento sull'utilità clinica del cateterismo cardiaco destro da sforzo.

Exercise RHC-3Decho to study the #RV contractile reserve in HFpEF and #PVD: exhausted reserve is associated with RV dilation and limited exercise capacity due to reduced CO reserve, and not pulmonary vascular load 🫁 Claudia Baratto, Sergio Caravita 🔗: jhltonline.org/article/S1053-…

Ever wondered what determines the hemodynamic impact of tricuspid regurgitation? What is the impact of RegVol/RegFr on RA V waves and on stroke volume? What the impact of RA compliance on RA V waves? Can we safely use indirect Fick in tricuspid regurgitation? Circ: Heart Failure 🧵👇

6/👇 Central illustration and link to the manuscript: ahajournals.org/doi/10.1161/CI…

Very well done study! Adds a lot to understanding of TR through multi modalities. Read this thread, and, more importantly, the paper is very informative. Congrats Sergio Caravita, Claudia Baratto, & team!

Determinants of Right Heart Hemodynamic Derangement in Patients with and Without Tricuspid Regurgitation Gianfranco Parati MD, FESC Denisa Muraru CosmoGodino Marat Fudim, MD MHS Antonio Sorropago Jean-Luc Vachiery 🫀 Sergio Caravita Michele Tomaselli Luigi #AHAJournals ahajrnls.org/3I9kSDU

Gp 1 PH with high HFpEF probability have less clinical improvement with traditional PH therapy, compared to gp 1 PH + low HFpEF prob. Do we need more intensive PH therapy, sotatercept or HFpEF therapies for these pts? Many unknowns that need RCTs. publications.ersnet.org/content/erj/ea…

Screening for comorbid autonomic dysfunction and/or preload insufficiency may ultimately become a necessary approach when we consider preload reduction therapies in HFpEF. Nice analysis here by Andrew J Sauer MD @hfpef and colleagues! Vishal Rao Marat Fudim, MD MHS Yogesh Reddy

Important work led by💫Yale Cardiology fellow Mandana Chitsazan MD MPH and the Jennifer Ho lab, highlighting that individuals with obesity may require LOWER BNP cutoffs to be appropriately up-classified to Stage B HF. ahajrnls.org/3JxnFHv

SGLT2i use is associated with improved outcomes in very elderly patients with heart failure and high comorbidity burden Hakim #AHAJournals ahajrnls.org/3JzxO6x

👀 Dynamics of AFMR during #ExerciseEchocardiography #CPETecho in JACC Journals ✨ TEAM ✨ Sebastiaan Dhont Wouter L’Hoyes Sara Moura Ferreira Philippe B. Bertrand 👇

Novel Devices for #HFpEF 🔥 #ELEVATEHFpEF Personalized Pacing #CASTLEHFpEF AF Ablation #AIMHigher Cardiac Contractility Modulator #RESPONDERHF #ALLAY Interatrial Shunt #REBALANCE Splanchnic Nerve Ablation #ALLEVIATEHF Insertable Monitor Watch this space! jacc.org/doi/10.1016/j.…