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Excellent correspondence in The Lancet by Clare Turnbull- Prof/NHS Dr and Richard Sullivan about Grail-Galleri test , 989 $ blood test which claims to detect 50 cancers . With sensitivity of 27.5 % for early stages , this is surprising that NHS England is even considering this for mass

🚨 BREAKING - Road occupied at Strand outside the Royal Courts of Justice. Over 1,000 people are sat in the street holding a time-limited Exhibition in solidarity with the ‘Lord’ Walney 16. The People will not be deterred by extreme sentences of peaceful protestors. 🧵

Clare Turnbull- Prof/NHS Dr presenting about SMARCA4 pathogenic variants penetrance in SCCOHT( Small cell carcinoma of the ovary, hypercalcemic type ) #CGS2025 UK Clinical Genetics

A study calls for a limit to global warming to 2°C to avoid detrimental impacts on crop diversity and production in more than half of global cropland areas. Especially affecting the tropics where many of the world’s most vulnerable nations are located. nature.com/articles/s4301…

This is what happens when you take top science and try to replicate the basic finding. It's dishonest not to admit that there is a huge problem in science.

Huge thanks Dra. María Natalia Gandur Quiroga for an excellent summary of our paper. We have just finished new WES sequencing of 7800 cases of TGCT (so a goof five-fold more than this analysis!) and will analyse against UKBiobank. So let's see where that takes us!

already voted for Dr Asif Qasim MA PhD FRCP

Just watched Sir Gareth Southgate deliver The Richard Dimbleby Lecture 2025 on BBC One . It is utterly outstanding - superbly composed , brilliantly delivered , compelling , bold and true . Its really is what we pay our licence fee for . You can watch it here . . .

For the first time, scientists have analysed mutations in stomach lining tissue to reveal the earliest stages of cancer. The team also uncovered a potential new cause of stomach cancer, which needs further research 🔎 sanger.ac.uk/news_item/earl…

How difficult can it be to run the GMC? You provide a monopoly service because no one else in the UK can register and regulate doctors. You decide how much doctors will pay you each year. And you are not at all accountable to doctors because they have no say in who runs the GMC.

See our new paper in AJHG : Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists Explores blocks to implementation of MAVE data into clinical variant interpretation ClinGen ACGS authors.elsevier.com/a/1lDFkgeXDyy6

Newly-released ESMO recommendations critically assess specific germline pathogenic variants in terms of cancer-related mortality and testing implications for patients and their families Read the full article in the #ESMODailyReporter 🔗 ow.ly/xpGT50W9PuY

ESMO - Eur. Oncology Clare Turnbull- Prof/NHS Dr Elena Castro G Curigliano MD PhD Ben Westphalen These new ESMO recommendations seem pivotal in understanding how specific germline pathogenic variants influence cancer mortality. It's interesting to consider how these findings might shape genetic testing approaches for individuals and families at risk. How do these

ESMO - Eur. Oncology Clare Turnbull- Prof/NHS Dr Elena Castro G Curigliano MD PhD Ben Westphalen Targeted gene testing like this shows how precision oncology can deliver meaningful results without unnecessary patient burdens. Strong guidelines from ESMO.

"The Catch in Catching Cancer Early" Excellent article by Siddhartha Mukherjee. Exploring the presumption that earlier detection improves outcomes

See the full paper here: annalsofoncology.org/article/S0923-… We recommend, based on evidence of mortality benefit of interventions, restriction of germline breast cancer panel testing to 7 genes. We must challenge the "more is better" model of gene inclusion on panels that NGS has driven.

ON BBC Panorama tonight - the story of Paloma Shemirani, a young woman with an 8cm lymphoma inside her chest, and an 85% chance of a cure with chemo. Her mother Kate, a nurse and conspiracy theorist convinced her to do Gerson Therapy (juicing and enemas) instead. A few months

Doctors call on The BMA to vote for improving NHS resilience in heatwaves for patients & NHS staff Health professionals shouldn’t have to work in intolerable heat because of Govt inaction on the climate crisis Time to act now. ⏰ #BMAARM25 healthforxr.com/23rd-june-2025…

I've long called for a wealth tax - and it’s great to see support for it growing stronger by the day. A 2% Wealth Tax on assets over £10 Million would raise £24 BILLION per year The public backs a Wealth Tax. Let's step up our campaigning to get the Government to introduce one!

Bad news for the Antarctic sea ice and everyone who relies on it being there (everyone) Ocean current scientists are very upset You should be too theguardian.com/commentisfree/…