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T1. Yes, vitamin D was included in milk particularly for prevention of rickets; however interestingly enough, vitamin D in the 1930s was added to beer #vitaminchat

T1. Megadoses can be a problem particularly for vitamin D from randomized trials where more falls and fractures occurred with the high dose intermittent supplementation #vitaminchat

T2. Agree with Dr. Kramer, part of the reason these supplements fall out of favor is because the randomized trials show no benefit. And those are the highest level of evidence #vitaminchat

T2. Marketing plays a big role in pushing these supplements; in answer to the question of a single multivitamin in a 61 year old woman, the answer rests with the health of the individual. #vitaminchat

T2 I am not sure that the body flushes out excess vitamins; certainly for vitamin D it can persist in fat tissue and the circulation for a prolonged period #vitaminchat

T2 All i can say is that the supplement business is a huge business; not only supplements but labs that measure the vitamin levels #vitaminchat

T2 Agree with Dr. nestle on healthy people becoming healthier; but many of these people take the supplements anyways; MAGICAL THINKING #vitaminchat

T3. Dose dependency is what most people believe, higher the better; certainly among Docs that i ask at conferences, they will take the highest dose of D- 5000/d - and they are docs!!! #vitaminchat

T3 The most recent meta-analysis (JAMA IntMedicine,2017) suggest routine calcium and vitamin D in healthy postmenopausal women does NOT reduce fracture risk; possibly helpful in those elders living in non-community situations

T3. There is a decline in the winter of serum vitamin D in northern latitudes of about 20%. Its not clear that this causes any harm unless of course levels are extremely low to begin with #vitaminchat

T4 For vitamin D, there is one large randomized control trial in nursing home patients who were vitamin D deficient that showed a 33% reduction in hip fractures with 800 IU vitamin D per day and 1200 mg Ca. Thats the only study that showed a significant benefit #vitaminchat

A new trial shows no benefits of vitamin D supplementation during pregnancy except that it increases blood levels of vitamin D #vitaminchat

T4 For community dwelling healthy older individuals, there are no data to suggest that vitamin D supplements prevent fractures- there is conflicting data as to whether it may reduce falls in the frail elderly #vitaminchat

T5 I am not saying not to take vitamin D supplements during pregnancy, just saying that high dose supplements of vitamin D do not prevent pre-eclampsia or hypertension. sorry for the confusion #vitaminchat

T5 Balanced diet is the best advice. And some sunlight!!! #vitaminchat

T5 No evidence from randomized trials that vitamin D supplementation helps multiple sclerosis; but some patients with MS who cant get outside and our bed bound might be vitamin D deficient and that is worth correcting #vitaminchat

T5 Agree that we are over testing for vitamin D!!! #vitaminchat

Vitamin D insufficiency is an artificial term and does not denote a disease-thats one problem with the idea of testing everyone #vitaminchat

thanks to everyone #vitaminchat

Learn about research careers at the young investigators forum. MMC Dana Auditorium June 22,2018. Sponsored by NNE-CTR