10,048,466! That’s a lot of #SARSCoV2 genomes in the single largest phylogeny ever that we update and optimize every single day! Here, I’ll explain how we are doing pandemic-scale phylogenomics.

Excited to share my first postdoctoral work (w/ Jan-Christian Huetter , Jonathan Pritchard , and Aviv Regev) about building causal models of gene regulation from pooled genetic screens data (aka. Perturb-seq), with a focus on scaling inference to thousands of variables. arxiv.org/abs/2206.07824

The Major Histocompatibility Complex (MHC) plays a critical role in immunity. It’s also very unusual, with 1000s of alleles, 1000s of GWAS hits, and trans-species polymorphism (TSP). Just how old is this TSP?? A 🧵 about my new preprint w/Jonathan Pritchard: (1/13) doi.org/10.1101/2022.0…

Our paper "Genetic diversity loss in the Anthropocene" is out in Science Magazine! We study how genetic diversity is lost by habitat loss to help define UN Biodiversity #Sustainable targets science.org/doi/10.1126/sc… @CarnegieScience Carnegie Plants Carnegie Ecology Stanford University

How do plants respond to climate change? We study the genomes of 200-year-old pressed plants and find that they may have evolved fewer leaf pores (but it is complicated - read the paper!👇) biorxiv.org/content/10.110…

Measures of gene constraint like pLI and LOEUF have been hugely useful in human genetics, but they lack power to detect constraint in the shortest 25% of genes. Here, we introduce an empirical Bayes framework (GeneBayes) to solve this problem. biorxiv.org/cgi/content/sh… 1/n

Rachel Ungar and I are thrilled to share our paper on the trainee-led course on genetics, ethics, and society that was developed at Stanford: biorxiv.org/content/10.110… (1/9)

A shift in the way people move in the Roman Empire - traveling, but not settling down. We analyzed hundreds of ancient human genomes, discovered high migration, & showed how the results fit with present-day population structure. Check out our new paper! 🧵elifesciences.org/articles/79714