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The group at Tenth Ward Distilling Company, where we go when we have thoughts to distill. Welcome to the lab, Nelly Nelly Mak!

Now online at JCI Journal of Clinical Investigation, we show that mTOR inhibitors promote cell entry of SARS-CoV2☣️and exacerbate viral disease. A great collaboration between NCI @NCIResearchCtr, NIAID jon yewdell Sonja Best and OSU Jacob Yount! #SARSCoV2 #COVID19 jci.org/articles/view/…

The fourth Special Issue of 2022 was "The Multifaceted Innate Response to Virus Infection" guest edited by Alex Compton National Cancer Institute. See the whole collection of research articles and reviews here: bit.ly/37rI1yP

Call for papers: if you have an idea or a story in progress on the topic of IFITM proteins, submit your manuscript to our Special Issue in Viruses Viruses MDPI (edited by myself and Chen Liang, McGill University). Tentative submission deadline is October mdpi.com/journal/viruse…

🔔My first manuscript is on bioRxiv!🦇Chinese horseshoe bats not only have antiviral IFITMs, they also generate IFITM diversity by alternative splicing which is distinct from the human IFITM family. #InnateImmunity #LoveVirology biorxiv.org/content/early/… 🧵1/7

Omicron Spike confers enhanced infectivity and interferon resistance to #SARSCoV2 in human nasal tissue Alex Compton nature.com/articles/s4146…

Interested in the intersection between SNARE fusion machinery and innate immunity? The latest preprint from the lab is posted while it's being peer-reviewed: SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion biorxiv.org/content/10.110…

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion Alex Compton and colleagues Alex Compton National Cancer Institute NIH embopress.org/doi/full/10.10…

Our latest discovery of how intrinsic immunity regulates SNARE activity to promote lysosomal delivery of cellular and viral cargo is now published in The EMBO Journal: embopress.org/doi/full/10.10… National Cancer Institute NIH

Happy to see our collaborative work on antiviral immunity in bats published in PLOS Pathogens: lnkd.in/eXzvRinS This study was led by grad student Nelly Mak of University of Edinburgh. Thanks to the UK Microbiology Society for supporting her time in my lab at the NCI!

New preprint from the lab: Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef biorxiv.org/content/10.110…