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We got a story, and it’s electric! 🔌⚡️ rdcu.be/dth70 Can electrocatalysis be used to precisely modify a protein? Yes! Happy to finally share this work led by Conor Loynd and Soumya Jyoti Singha Roy. A 🧵 #ProteinElectrochemistry #NSFfunded

They also demonstrated that, not surprisingly, eCLIC is compatible with both SPAAC and IEDDA. Combined with dual-ncAA mutagenesis to introduce 5HTP and an azide-ncAA, eCLIC+SPAAC can be cleanly and site-specifically double label a protein

New preprint by Quan Pham, on a facile strategy to attach any recombinant proteins onto AAV! The unparalleled precision it offers helped us generate retargeted AAV-nanobody conjugates with remarkable efficiency and selectivity in vitro and in vivo biorxiv.org/content/10.110…