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Result of a few brainstorming sessions with data management and data science experts from the industry and academia. It was great to hear from this group as the SGC embarks on a new mission to generate big data for drug discovery Structural Genomics Consortium (SGC) nature.com/articles/s4146…

Thank you, Matthieu and Structural Genomics Consortium (SGC) for organizing such an amazing challenge. It was so much fun to participate 👏 Team CMU-UBC FTW! 💪

A report detailing the results of the first CACHE #1 challenge, in which 23 computational teams each selected up to 100 commercially available compounds that they predicted would bind to the WDR domain of the Parkinson’s disease target LRRK2. biorxiv.org/content/10.110…

Check out the preprint bioRxiv detailing #CACHEChallenge 1! The success of these challenges is powered by the always excellent work of Matthieu & the SGC, as well as invaluable expertise and support of CACHE Members from Bayer AG and Boehringer Ingelheim #CADD #OpenScience

In collaboration with Boehringer Ingelheim, we present a comprehensive toolbox to support the generation of small molecule binders and chemical probes for the WWE domain-containing E3 ligases. nature.com/articles/s4200…

📣 New Funding Opportunity! 📣 We’re launching our Developing Medicines through Open Science program, to support open drug discovery in areas of market failure. Visit our website for more info (aussi en français!) & check for more details Aug 15! conscience.ca/developing-med…

Get ready for the 4th Probe Hackathon! Graduate students will get the chance to collaborate with experts and assess chemical probes to identify the most and least effective compounds for use in biological research. Merck Chemical Probes Portal chemicalprobes.org/hackathons/mer…

📣 Our Developing Medicines through Open Science program is now accepting LOIs. DMOS will support open drug discovery in areas like orphan diseases and antimicrobial resistance. Submit by Sept 27! conscience.ca/developing-med… #OpenScience #DrugDiscovery

Announcing CACHE2 results! Crowdsourcing and conventional methods did as well as novel ML. Teams started from 4 fragments in the PDB. We tested their predictions and found double-digit µM hits. This is the state-of-the-art. Structural Genomics Consortium (SGC) Conscience bit.ly/4dTPBzO

Devrions-nous nous sacrifier pour une noble cause ? Notre responsable des partenariats, Lauriane, pense que non. Elle est l’invitée du Dr David Mendes (Papa PhD) et y explique comment elle réconcilie emploi, impact sociétal et bonheur personnel. Bonne écoute ! papaphd.com/lauriane-gorce/

AI was supposed to revolutionize drug discovery—but it hasn’t. Yet. Hype, lack of data, and secrecy have hindered the progress many hoped for. We believe the key to unlocking AI's potential in drug discovery lies in #OpenScience and #RadicalCollaboration theglobeandmail.com/business/artic…

One week left to submit an LOI to our Developing Medicines through Open Science program! #OpenScience #DrugDiscovery #collaboration

This article features the top-performing Brazilian RFL-BAMBU team in our second CACHE Challenge. The team's outstanding success highlights why we actively encourage participation from teams in the Global South, bringing diverse perspectives and approaches to our Challenges.

We're excited see the #NobelPrize in chemistry and physics recognize advances crucial to our mission! These discoveries relied on high-quality, open data & exemplify the importance of quality and openness of data for the future of #AI in #DrugDiscovery conscience.ca/news/the-2024-…

Save the date for the second annual Conscience Symposium on Open Drug Discovery! Join us in Montreal on April 7-8, 2025, for two days dedicated to advancing open and AI-driven drug discovery. Learn more: conscience.ca/event/save-the…

A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease. pubs.acs.org/doi/10.1021/ac…