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When you share the floor with the most fun labs..Happy Halloween from the Filbin lab, Stegmaier Lab and hovestadt lab @dfci! 🎃👻💀

Happy Halloween from the Super Filbin Bros 🎃👻

Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental glial biology to stem cells and tumor biology. rdcu.be/d5ADz A 🧵(also come to 🦋!)

Excited to share a story spearheaded by the incredible Robin Sebastian where we describe a fundamental genome maintenance mechanism linking DNA replication with double-strand breaks nature! nature.com/articles/s4158… 🧵👇 1/n

White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity nature.com/articles/s4159…

Thrilled to share our work Mariella Filbin, @GojoJohannes, and Carl Koschmann, now published in Cancer Cell. We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations. cell.com/cancer-cell/fu…

Online Now: Effective targeting of PDGFRA-altered high-grade glioma with avapritinib dlvr.it/TJf5JV

Researchers from the lab of Mariella Filbin, MD, PhD, in collaboration with Michigan Medicine and the Medical University of Vienna, explore a potential new use for Avapritinib in treating aggressive gliomas. Learn more: bit.ly/4bJmTBk

Comprehensive interrogation of synthetic lethality in the DNA damage response | ⁦nature⁩ nature.com/articles/s4158…

1/✨New study out in Cell Reports Medicine ! - LaBelle & Haase et al. 2025 🧠🔬 Let's dive in to our latest collaborative work with Mariella Filbin & Kai Wucherpfennig! cell.com/cell-reports-m…

Excited to see our latest study on the immune landscape of pediatric high-grade glioma patients out! Tweetorial from fabulous Rebecca Pötschke below 👇🏻, we hope this will useful to many in the field! Dana-Farber/Boston Children's Boston Children's Dana-Farber Broad Institute #endbraincancer

We support all brain tumor patients and their families: past, present and future. Research is our most powerful path forward - and we are committed to advancing discoveries and delivering hope until there is a cure. #GoGrayInMay Dana-Farber/Boston Children's Dana-Farber Broad Institute

Online now: Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration dlvr.it/TKpZcB

Excited to share our first lab paper, now published in Developmental Cell! 🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?

Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species. Learn more in a new #SciencePerspective: scim.ag/3F4XJRP

Immensely proud of budding oncologist and future Dr. Ernesto Luna-Melendez for receiving the ASCO Conquer Cancer, the ASCO Foundation Medical Student Rotation Award!! 😍🥳

May is Brain Cancer Awareness Month. New research from the lab of Mariella Filbin, MD, PhD, suggests that avapritinib, an FDA-approved drug used to treat GI tumors, could also treat high-grade gliomas. Learn more. bit.ly/4j7pBm3

Thrilled to share that our paper is out in Nature Cancer! We used #scRNAseq, multiplexed spatial imaging, and eCLIP to study the cellular cooperation and transcriptional network in C19MC-driven #ETMR. Alexander Beck, Mariella Filbin, volker hovestadt 🧬 & Kool labs. nature.com/articles/s4301… 1/

Biggest congrats to Lisa, Alex and team for this beautiful work and the important insights into the biology of ETMR, a rare but highly aggressive childhood brain tumor!

Excited to share our new story on drivers and communication networks in a lethal tumor in young children called ETMR. Fantastic collaboration with volker hovestadt 🧬 and team! Dana-Farber Boston Children's Dana-Farber/Boston Children's Broad Institute #gograyinmay #endbraincancer 👇🏻👇🏻👇🏻