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Wanted: a reward for antibiotic development. Addressing the commercial failure of the antibiotic market should be a priority for governments seeking to encourage development of new drugs against resistant bugs go.nature.com/2lWk2g6 #antibioticresistance

And here are some malaria-infected red blood cells exploding (egressing) and releasing lots of malaria parasites to infect new host cells. The blue ones are missing a gene we have been studying at The Francis Crick Institute . Find out more at mbio.asm.org/content/9/4/e0…

This is a great opportunity... x.com/rayner_julian/…

Vaccines cause adults

We are delighted to announce that applications to the Wellcome Hosts, Pathogens & Global Health 4 year PhD Programme for 2019 are now OPEN! All details on the programme on our website! ow.ly/CuS830m0Ioe Keith Matthews Ross Fitzgerald @amybpedersen Tiba Partnership

High-throughput reformatting of phage-displayed antibody fragments to IgGs by one-step emulsion PCR academic.oup.com/peds/advance-a…

Rheumatoid arthritis patients express a skewed repertoire of polyclonal, hypomutated B-cell receptors biorxiv.org/cgi/content/sh… #bioRxiv

Our latest paper on B cell receptor repertoire sequencing in rheumatoid arthritis is on BioRxiv. RA patients' repertoires have much lower frequency of IgG mutations in peripheral B cell samples. #AIRRseq #antibodies #RepSeq

Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability - ScienceDirect sciencedirect.com/science/articl…

Let's just pause to reflect. 10 years for the first human genome. Now 10,000 human genomes/month. My thoughts a) 🤯 b) How many malaria parasite genomes could we run with that capacity? Chapeau to the amazing DNA Pipelines Wellcome Sanger Institute

Pleased to share with you our latest work in T-cell receptor structural analysis. TCRBuilder is a TCR modelling tool that incorporates binding site flexibility, crucial to the promiscuity in TCR binding. Oxford Protein Informatics Group (OPIG)

In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG+ve B Cells frontiersin.org/article/10.338…

Pleased to share our latest work on TCR repertoires in P chabaudi infection, now on BioRxiv: A Conserved TCRβ signature dominates a highly polyclonal T-cell expansion during the acute phase of a murine malaria infection biorxiv.org/content/10.110…

Loss of germinal centres in COVID. cell.com/cell/fulltext/…

Our latest paper in now published in Frontiers in Immunology! A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection frontiersin.org/article/10.338…

We’re pleased to introduce AIRRSHIP, a tool for simulating human B cell receptor repertoire sequences biorxiv.org/content/10.110…. AIRRSHIP is Python-based (run at command line or import as module), no dependencies, very easy to install. Docs @ airrship.readthedocs.io

📣Calling young African researchers! Apply for the Prof Ogobara K. Doumbo Fellowship for the opportunity to develop your knowledge and skills in malaria-related research. mmv.org/call-prof-ogob…