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Excited to share our discovery from Eric Brown lab of a novel antivirulence agent that reverses b-lactam resistance in MRSA. Was fun collaborating with David Heinrichs and McGavin Lab Western University and Mike Organ Ottawa University and Richard Epand McMaster University on this! nature.com/articles/s4158…

Amazing work by Shawn French and Amelia Guo on how to build a cheap DIY platform for capturing gene expression data.

Happy to share that our work Eric Brown lab uncovering the antibiotic potential of Cannabinoids is out Infectious Diseases. Was fun working with Maya Farha, Rob Gale, Craig MacNair, @LindseyCarfrae &Jake Magolan’s lab on this.McMaster IIDR @MacHealthSci pubs.acs.org/doi/10.1021/ac…

A Nature paper reports a new group of antibiotics with a unique approach to attacking bacteria, making it a clinical candidate in the fight against antimicrobial resistance. The drugs kill bacteria by blocking the function of the bacterial cell wall. go.nature.com/2HoSScs

Amazing work from former Brown Lab member Jon Stokes.

Fantastic job here by Kristina Klobucar and the team. Biggest gene-gene/chemical-gene network undertaking to date by our group!

Proud to be a part of this project. Check out Caressa Tsai 's cool new antivirulence approach targeting two-component systems in Salmonella!

I continue to be amazed by the contribution of physiological bicarbonate to antibiotic action. Very proud of this effort led by Maya Farha. Good fun as always to work with @agmcarthur laboratory. pubs.acs.org/doi/10.1021/ac…

If your antibiotic discovery strategy involves targeting the outer membrane of Gram-negs, it's good to know that pesky resistance mechanisms may not spoil the party. Lovely work here by Craig MacNair who takes a thorough approach this question. mbio.asm.org/content/11/5/e…

OK, #Canadian scientists, #science students, science influencers, scientific societies, student & postdoc unions, and everyone else who may know someone w/ science postgraduate training We (COVID-19 Resources Canada ) and the province of #Ontario really need your help...every one of you.

Join us (@gerryiidr Miller Lab Sawayra Owais 🐋 Dr. Schwartz and myself) for a panel discussion on #Pandemics on May 20, 9.30 am EST. Registration: hopin.com/events/faculty… McMaster Health Sciences McMaster FHS Faculty Affairs VIDO

This is as important as it sounds, and increases the likelihood that we can develop a vaccine that will protect against not just new variants of SARS-CoV-2, but all coronaviruses - including ones we don't know about yet.

Great fun collaborating with the Hung and Magolan groups on the discovery of new small molecule probes of the Gram-negative outer membrane. Tremendous leadership by Kristina Klobucar and a huge effort by J-P Côté! pubs.acs.org/doi/10.1021/ac…

We've posted a new #MacTheobio COVID forecast for Ontario. mac-theobio.github.io/forecasts/outp… irena papst, phd 👩‍💻📉🦠 @mliwz1 @bolkerb David Earn

Happy to announce our research article on stress responses in many human bacterial pathogens is out in Nature Communications. Thanks to all labs helped us specially Karsten Borgwardt and TangLab nature.com/articles/s4146…

Tonight the #CNTower will be lit light blue for World Antimicrobial Awareness Week / Ce soir la #TourCN sera illuminée en bleu pâle pour la Semaine mondiale pour un bon usage des antimicrobiens

GENERATIVE AI ALERT... Working with our amazing friends James Zou and Kyle Swanson, we developed SyntheMol, a generative AI model that designs novel antibacterial molecules that are synthetically tractable and cheap to make! LOVE YOU! nature.com/articles/s4225…

Shawn French and team are 3D printing their way to new antibacterial chemical matter of unusual mechanism. Here, a semi-synthetic natural product (probably) hits the allosteric site of DNA gyrase. sciencedirect.com/science/articl…