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NIH - US cases of #ChronicPain outnumber those for diabetes, depression, and high blood pressure! Human genetic and preclinical studies highlight the benefit of #BH4 inhibition. Important to keep the inhibition in the periphery. Why? And How? 👇 frontiersin.org/articles/10.33…

Recent bioRxiv manuscript from Shane JF Cronin PenningerLab & colleagues highlights the importance of the multi-faceted roles that the GCH1/BH4 metabolic pathway play in maintaining dopamine neurons & a potential therapeutic target for #Parkinsons; biorxiv.org/content/10.110…

This is the most personal piece I've ever written. It's about my last three years living with chronic pain - the mystery, the loneliness, and the failures of the system. (Warning: discusses self harm and suicidal thoughts.) theguardian.com/society/2023/j…

Our recent study highlighting the role of ATM kinase in melanoma invasion and metastasis is out now in PNAS PNASNews. Please check it out @ pubmed.ncbi.nlm.nih.gov/37963252/ Rohit Jain, PhD.

We discovered that the density of T cells in a 3D matrix induces a high-motility state via secretion of specific cytokines. Expression of corresponding "velocity receptors" in T cells "lock in" that state. The resulting cells penetrate solid tumors! biorxiv.org/content/10.110…

As life expectancy increases, understanding the complexities of aging becomes ever more crucial. PenningerLab, Domagoj Cikes, and others, discuss the role of lipid pathways in aging and the synchronization of cells. nature.com/articles/s4358…

Biogen to cease production of controversial Alzheimer's drug ow.ly/1BAH105eJoH

GLP1 agonists help with opioid cravings, reports a STAT article based on the data presented at the American Association for the Advancement of Science conference. Likely the first of many such readouts we'll hear this year. statnews.com/2024/02/17/opi…

🔬 Join us on a journey of discovery! 🚀 PhD Opportunity! 🎓Our lab at MedUni Wien is now accepting applications for a PhD candidate. 🩸🧫 Shape the future in blood vessel and bone marrow organoid research. Apply online by 15.04.2024, 23:55CET at bit.ly/3l7WMhs

We are delighted to share our latest study published in science translational medicine! Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain | Science Translational Medicine science.org/doi/10.1126/sc…

Immune drivers of physiological and pathological pain. A new Perspective from Aakanksha Jain (Aakanksha Jain), Sara Hakim (Sara Hakim), and Clifford J. Woolf Boston Children's: hubs.la/Q02sSn0j0 #InnateImmunity #inflammation #Neuroscience #Neuroinflammation

Together with Philipp Starkl we are looking for a joint master student in infectious diseases research. Details below - we are looking forward to your application (deadline May 31st, 2024)

Congratulations Shweta Tikoo for being awarded Researcher of the Month by the Medical University of Vienna. meduniwien.ac.at/web/forschung/… youtube.com/watch?v=1nj6tp…

📌 Researchers have made progress in understanding the mechanisms that influence pain sensation after surgery! ↪️ The findings of a group led by #MedUniVienna & IMBA imbavienna.bsky.social reveal a new possibility for localised and targeted therapy. ➡ bit.ly/3YQbVWj Science Immunology

Beautiful image taken by Rohit Jain, PhD. and Shweta Tikoo, showing #mastcell granules (yellow) in close proximity to #pain neurons (magenta) including the substance P specific-subset (cyan) in the mouse skin > scim.ag/87H

Stoked to share the most recent paper from the lab, starring #MastCells, the probably most interesting #ImmuneCells around..at least for some people in the group (Philipp Starkl). FANTASTIC collaboration with Shane JF Cronin PenningerLab science.org/doi/10.1126/sc…

New research from Shane JF Cronin and Josef Penninger at the PenningerLab and Philipp Starkl at MedUni Wien shows that reducing production of the neuropathic pain mediator molecule BH4 could effectively treat chronic postoperative pain. More info: bit.ly/3T0238D

Turn down the pain, turn up the gain: Our new paper on peripheral pain targets is out Genetics Society of America. Work by Zina Hamoudi and others Charles Perkins Centre Sydney Science doi.org/10.1093/g3jour… We tested 100s of potential targets and identified 23 new pain genes. Please RT